ArticleCardiovascular diabetology2013
Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study.
Article in Cardiovascular diabetology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Health Benefits of Endurance Training: Implications of the Brain-Derived Neurotrophic Factor-A Systematic Review.Neural plasticity · 2019Pooled it
- Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs.Cardiovascular diabetology · 2014Trial
- The Association Between Race/Ethnicity and Risk of Type 2 Diabetes in Women Varies by BMI: A Pooled Analysis of Individual Data From 15 Cohort Studies.Diabetes care · 2026Article
- Association between plasma glucose-dependent insulinotropic polypeptide and active adiponectin in normoglycemic women.Endocrine connections · 2026Article
- Harnessing adiponectin for sepsis: current knowledge, clinical insights and future therapies.Critical care (London, England) · 2025Review
- Hip BMD is associated with visceral fat change: a registry study of osteoporosis and sarcopenia.Therapeutic advances in chronic disease · 2022Article
- Postprandial Metabolism and Physical Activity in Asians: A Narrative Review.International journal of sports medicine · 2021Review
- Circulating microRNAs associated with prediabetes and geographic location in Latinos.International journal of diabetes in developing countries · 2021Article
- Type 2 Diabetes and Atherosclerotic Cardiovascular Disease in South Asians: a Unique Population with a Growing Challenge.Current diabetes reports · 2020Review
- Adiponectin: Role in Physiology and Pathophysiology.International journal of preventive medicine · 2020Review
- Total adiponectin in overweight and obese subjects and its response to visceral fat loss.BMC endocrine disorders · 2019Article
- Body Composition and Diabetes Risk in South Asians: Findings From the MASALA and MESA Studies.Diabetes care · 2019Article
- Large-for-Gestational-Age May Be Associated With Lower Fetal Insulin Sensitivity and β-Cell Function Linked to Leptin.The Journal of clinical endocrinology and metabolism · 2018Article
- The relationship among serum lipocalin 2, bone turnover markers, and bone mineral density in outpatient women.Endocrine · 2018Article
- Development of metabolic syndrome in high-sucrose diet fed rats is not associated with decrease in adiponectin levels.Endocrine · 2017Article
- Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Disease Severity.Journal of immunology research · 2017Article
- Article
- Less favorable body composition and adipokines in South Asians compared with other US ethnic groups: results from the MASALA and MESA studies.International journal of obesity (2005) · 2016Article
- Sensitivity of various adiposity indices in identifying cardiometabolic diseases in Arab adults.Cardiovascular diabetology · 2015Article
- Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients.BMC endocrine disorders · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEthnic-specific differences in insulin resistance (IR) are well described but the underlying mechanisms are unknown. Adiponectin is an insulin sensitizing adipocytokine that circulates as multiple isoforms, with high molecular weight (HMW) adiponectin associated with greatest insulin sensitivity. The objective of this study is to determine if plasma total and HMW adiponectin concentrations underlie ethnic-specific differences in IR.
methodsHealthy Canadian Aboriginal, Chinese, European, and South Asian adults (N = 634) were assessed for sociodemographics; lifestyle; fasting plasma insulin, glucose, and total and HMW adiponectin; and adiposity measures [BMI, waist circumference, waist-to-hip ratio, percent body fat, and subcutaneous and visceral adipose tissue (quantified by computed tomography)]. The homeostasis model assessment-insulin resistance (HOMA-IR) assessed IR.
resultsSouth Asians had the greatest HOMA-IR, followed by Aboriginals, Chinese, and Europeans (P < 0.001). Plasma total and HMW adiponectin concentrations were lower in Chinese and South Asians than Aboriginal and Europeans (P < 0.05). Total and HMW adiponectin were inversely associated with HOMA-IR (P < 0.001). Ethnicity modified the relationship between HMW adiponectin and HOMA-IR with stronger effects observed in Aboriginals (P = 0.001), Chinese (P = 0.002), and South Asians (P = 0.040) compared to Europeans. This was not observed for total adiponectin (P = 0.431). At mean total adiponectin concentrations South Asians had higher HOMA-IR than Europeans (P < 0.001).
conclusionsFor each given decrease in HMW adiponectin concentrations a greater increase in HOMA-IR is observed in Aboriginals, Chinese, and South Asians than Europeans. Ethnic-specific differences in HMW adiponectin may account for differences in IR.
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