ArticleBMC cardiovascular disorders2013
Post-stress left ventricular ejection fraction drop in patients with diabetes: a gated myocardial perfusion imaging study.
Article in BMC cardiovascular disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Patient centric performance and interpretation of SPECT and SPECT/CT myocardial perfusion imaging: a clinical consensus statement of the European Association of Cardiovascular Imaging of the ESC.European heart journal. Imaging methods and practice · 2025Review
- Low-dose dobutamine stress gated blood pool SPECT assessment of left ventricular contractile reserve in ischemic cardiomyopathy: a feasibility study.European journal of nuclear medicine and molecular imaging · 2022Article
- Prognostic significance of post-stress reduction in left ventricular ejection fraction with adenosine stress in Jordanian patients with normal myocardial perfusion.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- How variable are the volumetric measurements from gated perfusion SPECT when a one-day stress-rest protocol is used?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Diagnosis and Prognosis of Coronary Artery Disease with SPECT and PET.Current cardiology reports · 2019Review
- Gender- and age-related differences in rest and post-stress left ventricular cardiac function determined by gated SPECT.The international journal of cardiovascular imaging · 2014Article
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8 authors.
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Abstract
backgroundTo evaluate the relevance of stress-induced decrease in left ventricular ejection fraction (LVEF) in patients with type-2 diabetes.
methodsA total of 684 diabetic patients with available rest and post-stress gated myocardial perfusion single-photon emission computed tomography (MPS) data were enrolled. An automated algorithm was used to determine the perfusion scores using a 17-segment model. LVEF drop was considered significant if the post-stress LVEF was ≥5% below the rest value. Follow-up data were available in 587 patients that were followed for the occurrence of cardiac death, nonfatal myocardial infarction, or unstable angina requiring revascularization.
resultsA post-stress LVEF drop ≥5% was observed in 167 (24%) patients. Patients with LVEF drop had higher summed stress score (p < 0.05), summed difference score (p < 0.001), and rest LVEF (p < 0.001) compared to patients without. Conversely, summed rest score, a measure of infarct size, was comparable between the two groups. At multivariable analysis, summed difference score and rest LVEF were independent predictors (both p < 0.001) of post-stress LVEF drop. Myocardial perfusion was abnormal in 106 (63%) patients with post-stress LVEF drop and in 296 (57%) of those without (p = 0.16). The overall event-free survival was lower in patients with post-stress LVEF drop than in those without (log rank χ2 7.7, p < 0.005). After adjusting for clinical data and MPS variables, the hazard ratio for cardiac events for post-stress LVEF drop was 1.52 (p < 0.01).
conclusionsIn diabetic patients stress-induced ischemia is an independent predictor of post-stress LVEF drop; however, a reduction in LVEF is detectable also in patients with normal perfusion. Finally, post-stress LVEF drop increases the risk of subsequent cardiac events in diabetic patients.
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