ArticleBioMed research international2013
Suppressions of serotonin-induced increased vascular permeability and leukocyte infiltration by Bixa orellana leaf extract.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Anti-Inflammatory and Antimicrobial Activities of Extracts Developed fromInternational journal of molecular sciences · 2026Article
- Antiarthritic and Anti-Inflammatory Properties ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Ethyl Acetate Fraction ofAntibiotics (Basel, Switzerland) · 2022Article
- Anti-Inflammatory and Anti-Angiogenic Aattributes ofFrontiers in pharmacology · 2022Article
- Anti-Inflammatory Medicinal Plants of Bangladesh-A Pharmacological Evaluation.Frontiers in pharmacology · 2022Review
- Chemical Characterization and Anti-Inflammatory Activity of Phytoconstituents fromPlants (Basel, Switzerland) · 2021Article
- Investigation of in vivo anti-inflammatory and anti-angiogenic attributes of coumarin-rich ethanolic extract of Melilotus indicus.Inflammopharmacology · 2021Article
- Evaluation of in vivo anti-inflammatory and anti-angiogenic attributes of methanolic extract of Launaea spinosa.Inflammopharmacology · 2020Article
- Hydroalcoholic Extract and Ethyl Acetate Fraction ofEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Bixa orellana leaf extract suppresses histamine-induced endothelial hyperpermeability via the PLC-NO-cGMP signaling cascade.BMC complementary and alternative medicine · 2015Article
- Egg white-induced inflammation models: A study of edema profile and histological change of rat's paw.Journal of advanced pharmaceutical technology & researchArticle
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Authors and funding
7 authors.
Funding
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Abstract
The aim of the present study was to evaluate the anti-inflammatory activities of aqueous extract of Bixa orellana (AEBO) leaves and its possible mechanisms in animal models. The anti-inflammatory activity of the extract was evaluated using serotonin-induced rat paw edema, increased peritoneal vascular permeability, and leukocyte infiltrations in an air-pouch model. Nitric oxide (NO), indicated by the sum of nitrites and nitrates, and vascular growth endothelial growth factor (VEGF) were measured in paw tissues of rats to determine their involvement in the regulation of increased permeability. Pretreatments with AEBO (50 and 150 mg kg⁻¹) prior to serotonin inductions resulted in maximum inhibitions of 56.2% of paw volume, 45.7% of Evans blue dye leakage in the peritoneal vascular permeability model, and 83.9% of leukocyte infiltration in the air-pouch model. 57.2% maximum inhibition of NO and 27% of VEGF formations in rats' paws were observed with AEBO at the dose of 150 mg kg⁻¹. Pharmacological screening of the extract showed significant (P < 0.05) anti-inflammatory activity, indicated by the suppressions of increased vascular permeability and leukocyte infiltration. The inhibitions of these inflammatory events are probably mediated via inhibition of NO and VEGF formation and release.
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