ArticleSystems biomedicine (Austin, Tex.)2013
Toward plasmonics-enabled spatiotemporal activity patterns in three-dimensional culture models.
Article in Systems biomedicine (Austin, Tex.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 14 citations in OpenAlex.
- Phase intensity nanoscope (PINE) opens long-time investigation windows of living matter.Nature communications · 2023Article
- Optical Penetration of Shape-Controlled Metallic Nanosensors across Membrane Barriers.Sensors (Basel, Switzerland) · 2023Article
- Intelligent Fusion Imaging Photonics for Real-Time Lighting Obstructions.Sensors (Basel, Switzerland) · 2022Article
- Reversible Aptamer-Au Plasmon Rulers for Secreted Single Molecules.Nano letters · 2015Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Spatiotemporal activity patterns of proteases such as matrix metalloproteinases and cysteine proteases in organs have the potential to provide insight into how organized structural patterns arise during tissue morphogenesis and may suggest therapeutic strategies to repair diseased tissues. Toward imaging spatiotemporal activity patterns, recently increased emphasis has been placed on imaging activity patterns in three-dimensional culture models that resemble tissues in vivo. Here, we briefly review key methods, based on fluorogenic modifications either to the extracellular matrix or to the protease-of-interest, that have allowed for qualitative imaging of activity patterns in three-dimensional culture models. We highlight emerging plasmonic methods that address significant improvements in spatial and temporal resolution and have the potential to enable quantitative measurement of spatiotemporal activity patterns with single-molecule sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.