ArticlePloS one2013
Developmental switch in neurovascular coupling in the immature rodent barrel cortex.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- 7 Tesla fMRI characterisation of the cortical-depth-dependent BOLD response in early human development.bioRxiv : the preprint server for biology · 2025Article
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
- In mice and humans, brain microvascular contractility matures postnatally.Brain structure & function · 2023Article
- Cerebral haemodynamic response to somatosensory stimulation in preterm lambs is enhanced following sildenafil and inhaled nitric oxide administration.Frontiers in physiology · 2023Article
- Contribution of Interneuron Subtype-Specific GABAergic Signaling to Emergent Sensory Processing in Mouse Somatosensory Whisker Barrel Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Early brain activity: Translations between bedside and laboratory.Progress in neurobiology · 2022Review
- Cerebral haemodynamic response to somatosensory stimulation in preterm lambs and 7-10-day old lambs born at term: Direct synchrotron microangiography assessment.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Sulforaphane Ameliorates Metabolic Changes Associated With Status Epilepticus in Immature Rats.Frontiers in cellular neuroscience · 2022Article
- Regulation of the Cerebral Circulation During Development.Comprehensive Physiology · 2021Article
- Postnatal development of cerebrovascular structure and the neurogliovascular unit.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- Electroencephalographic features of discontinuous activity in anesthetized infants and children.PloS one · 2019Article
- Article
- Cerebral haemodynamic response to somatosensory stimulation in neonatal lambs.The Journal of physiology · 2017Article
- Binaural blood flow control by astrocytes: listening to synapses and the vasculature.The Journal of physiology · 2017Review
- Cerebral haemodynamic response to somatosensory stimulation in near-term fetal sheep.The Journal of physiology · 2017Article
- Developmental Changes in Sensory-Evoked Optical Intrinsic Signals in the Rat Barrel Cortex.Frontiers in cellular neuroscience · 2017Article
- Article
- Interpreting BOLD: towards a dialogue between cognitive and cellular neuroscience.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Rapid Postnatal Expansion of Neural Networks Occurs in an Environment of Altered Neurovascular and Neurometabolic Coupling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurovascular coupling (NVC) in the adult central nervous system (CNS) is a mechanism that provides regions of the brain with more oxygen and glucose upon increased levels of neural activation. Hemodynamic changes that go along with neural activation evoke a blood oxygen level-dependent (BOLD) signal in functional magnetic resonance imaging (fMRI) that can be used to study brain activity non-invasively. A correct correlation of the BOLD signal to neural activity is pivotal to understand this signal in neuronal development, health and disease. However, the function of NVC during development is largely unknown. The rodent whisker-to-barrel cortex is an experimentally well established model to study neurovascular interdependences. Using extracellular multi-electrode recordings and laser-Doppler-flowmetry (LDF) we show in the murine barrel cortex of postnatal day 7 (P7) and P30 mice in vivo that NVC undergoes a physiological shift during the first month of life. In the mature CNS it is well accepted that cortical sensory processing results in a rise in regional cerebral blood flow (rCBF). We show in P7 animals that rCBF decreases during prolonged multi-whisker stimulation and goes along with multi unit activity (MUA) fatigue. In contrast at P30, MUA remains stable during repetitive stimulation and is associated with an increase in rCBF. Further we characterize in both age groups the responses in NVC to single sensory stimuli. We suggest that the observed shift in NVC is an important process in cortical development that may be of high relevance for the correct interpretation of brain activity e.g. in fMRI studies of the immature central nervous system (CNS).
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