ArticlePloS one2013
Global transcriptome analysis of Lactococcus garvieae strains in response to temperature.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Valorisation of cheese whey into single-cell protein by Lactococcus garvieae: dual waste nitrogen supplementation and uncertainty-informed process evaluation.World journal of microbiology & biotechnology · 2026Article
- Comparative Genomic Analyses of Lactococcus garvieae Isolated from Bovine Mastitis in China.Microbiology spectrum · 2023Article
- Detection of virulence-related genes in Lactococcus garvieae and their expression in response to different conditions.Folia microbiologica · 2018Article
- Transcriptome and Proteome of Fish-PathogenicFrontiers in microbiology · 2018Article
- Temperature-Dependent Gene Expression inFrontiers in microbiology · 2018Article
- Transcriptomic Analysis of Laribacter hongkongensis Reveals Adaptive Response Coupled with Temperature.PloS one · 2017Article
- The Hybrid Strategy ofFrontiers in microbiology · 2017Article
- Early Transcriptome Response ofFrontiers in microbiology · 2017Article
- Microbial forensics: predicting phenotypic characteristics and environmental conditions from large-scale gene expression profiles.PLoS computational biology · 2015Article
- Temperature-dependent expression of virulence genes in fish-pathogenic bacteria.Frontiers in microbiology · 2015Review
- Lactococcus garvieae: a small bacteria and a big data world.Health information science and systems · 2015Article
- Functional genomics of lactic acid bacteria: from food to health.Microbial cell factories · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactococcus garvieae is an important fish and an opportunistic human pathogen. The genomic sequences of several L. garvieae strains have been recently published, opening the possibility of global studies on the biology of this pathogen. In this study, a whole genome DNA microarray of two strains of L. garvieae was designed and validated. This DNA microarray was used to investigate the effects of growth temperature (18°C and 37°C) on the transcriptome of two clinical strains of L. garvieae that were isolated from fish (Lg8831) and from a human case of septicemia (Lg21881). The transcriptome profiles evidenced a strain-specific response to temperature, which was more evident at 18°C. Among the most significant findings, Lg8831 was found to up-regulate at 18°C several genes encoding different cold-shock and cold-induced proteins involved in an efficient adaptive response of this strain to low-temperature conditions. Another relevant result was the description, for the first time, of respiratory metabolism in L. garvieae, whose gene expression regulation was temperature-dependent in Lg21881. This study provides new insights about how environmental factors such as temperature can affect L. garvieae gene expression. These data could improve our understanding of the regulatory networks and adaptive biology of this important pathogen.
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