ArticlePloS one2013
Productive infection of human skeletal muscle cells by pandemic and seasonal influenza A(H1N1) viruses.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 40 citations in OpenAlex.
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- Impaired muscle stem cell function and abnormal myogenesis in acquired myopathies.Bioscience reports · 2023Review
- Elimination of receptor binding by influenza hemagglutinin improves vaccine-induced immunity.NPJ vaccines · 2022Article
- Zika virus disrupts gene expression in human myoblasts and myotubes: Relationship with susceptibility to infection.PLoS neglected tropical diseases · 2022Article
- The Musculoskeletal Involvement After Mild to Moderate COVID-19 Infection.Frontiers in physiology · 2022Review
- Acute and chronic neurological disorders in COVID-19: potential mechanisms of disease.Brain : a journal of neurology · 2021Review
- Muscle involvement in SARS-CoV-2 infection.European journal of neurology · 2021Article
- Influenza A-induced rhabdomyolysis with acute renal failure following a deep tissue massage.Proceedings (Baylor University. Medical Center) · 2021Article
- Influenza-associated myositis: a single-centre, 5-year retrospective study.European journal of pediatrics · 2021Article
- Rare complication of four extremity compartment syndrome requiring fasciotomy from influenza A viral myositis.BMJ case reports · 2021Article
- Influenza Infection has Fiber Type-Specific Effects on Cellular and Molecular Skeletal Muscle Function in Aged Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Case Report: Rhabdomyolysis in a Patient with COVID-19: A Proposed Diagnostic-Therapeutic Algorithm.The American journal of tropical medicine and hygiene · 2020Article
- Differentiation-dependent susceptibility of human muscle cells to Zika virus infection.PLoS neglected tropical diseases · 2020Article
- Localization Analysis of Heterophilic Antigen Epitopes of H1N1 Influenza Virus Hemagglutinin.Virologica Sinica · 2019Article
- Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses.Molecular therapy. Methods & clinical development · 2019Article
- Generation of Yellow Fever virus vaccine in skeletal muscle cells of chicken embryos.Memorias do Instituto Oswaldo Cruz · 2019Article
- Severe Influenza A(H1N1) Virus Infection Complicated by Myositis, Refractory Rhabdomyolysis, and Compartment Syndrome.Case reports in medicine · 2019Article
- Influenza-induced rhabdomyolysis.BMJ case reports · 2018Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Besides the classical respiratory and systemic symptoms, unusual complications of influenza A infection in humans involve the skeletal muscles. Numerous cases of acute myopathy and/or rhabdomyolysis have been reported, particularly following the outbreak of pandemic influenza A(H1N1) in 2009. The pathogenesis of these influenza-associated myopathies (IAM) remains unkown, although the direct infection of muscle cells is suspected. Here, we studied the susceptibility of cultured human primary muscle cells to a 2009 pandemic and a 2008 seasonal influenza A(H1N1) isolate. Using cells from different donors, we found that differentiated muscle cells (i. e. myotubes) were highly susceptible to infection by both influenza A(H1N1) isolates, whereas undifferentiated cells (i. e. myoblasts) were partially resistant. The receptors for influenza viruses, α2-6 and α2-3 linked sialic acids, were detected on the surface of myotubes and myoblasts. Time line of viral nucleoprotein (NP) expression and nuclear export showed that the first steps of the viral replication cycle could take place in muscle cells. Infected myotubes and myoblasts exhibited budding virions and nuclear inclusions as observed by transmission electron microscopy and correlative light and electron microscopy. Myotubes, but not myoblasts, yielded infectious virus progeny that could further infect naive muscle cells after proteolytic treatment. Infection led to a cytopathic effect with the lysis of muscle cells, as characterized by the release of lactate dehydrogenase. The secretion of proinflammatory cytokines by muscle cells was not affected following infection. Our results are compatible with the hypothesis of a direct muscle infection causing rhabdomyolysis in IAM patients.
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