ArticlePloS one2013
Adherens junction distribution mechanisms during cell-cell contact elongation in Drosophila.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- An adaptive microscope for the imaging of biological surfaces.Light, science & applications · 2021Article
- Elongated Cells Drive Morphogenesis in a Surface-Wrapped Finite-Element Model of Germband Retraction.Biophysical journal · 2019Article
- Actomyosin contractility modulates Wnt signaling through adherens junction stability.Molecular biology of the cell · 2019Article
- Cross-over endocytosis of claudins is mediated by interactions via their extracellular loops.PloS one · 2017Article
- Pathway to a phenocopy: Heat stress effects in early embryogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Dynamin-mediated endocytosis is required for tube closure, cell intercalation, and biased apical expansion during epithelial tubulogenesis in the Drosophila ovary.Developmental biology · 2016Article
- Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.Journal of cell science · 2015Article
- The transmembrane protein Crumbs displays complex dynamics during follicular morphogenesis and is regulated competitively by Moesin and aPKC.Development (Cambridge, England) · 2015Article
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Authors and funding
2 authors.
Funding
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Abstract
During Drosophila gastrulation, amnioserosa (AS) cells flatten and spread as an epithelial sheet. We used AS morphogenesis as a model to investigate how adherens junctions (AJs) distribute along elongating cell-cell contacts in vivo. As the contacts elongated, total AJ protein levels increased along their length. However, genetically blocking this AJ addition indicated that it was not essential for maintaining AJ continuity. Implicating other remodeling mechanisms, AJ photobleaching revealed non-directional lateral mobility of AJs along the elongating contacts, as well as local AJ removal from the membranes. Actin stabilization with jasplakinolide reduced AJ redistribution, and live imaging of myosin II along elongating contacts revealed fragmented, expanding and contracting actomyosin networks, suggesting a mechanism for lateral AJ mobility. Actin stabilization also increased total AJ levels, suggesting an inhibition of AJ removal. Implicating AJ removal by endocytosis, clathrin endocytic machinery accumulated at AJs. However, dynamin disruption had no apparent effect on AJs, suggesting the involvement of redundant or dynamin-independent mechanisms. Overall, we propose that new synthesis, lateral diffusion, and endocytosis play overlapping roles to populate elongating cell-cell contacts with evenly distributed AJs in this in vivo system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.