ArticlePloS one2013
Serotonin receptor B may lock the gate of PTTH release/synthesis in the Chinese silk moth, Antheraea pernyi; a diapause initiation/maintenance mechanism?
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 54 citations in OpenAlex.
- The serotonin receptor AmFrontiers in physiology · 2026Article
- Melatonergic Regulation of Polyethism and Circadian Foraging inInternational journal of molecular sciences · 2025Article
- Larval diapause slows adult epigenetic aging in an insect model,Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Divergence in cell cycle progression is associated with shifted phenology in a multivoltine moth: the European corn borer, Ostrinia nubilalis.The Journal of experimental biology · 2023Article
- Article
- Circadian and Neuroendocrine Basis of Photoperiodism Controlling Diapause in Insects and Mites: A Review.Frontiers in physiology · 2022Review
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- The Modulation of Trehalose Metabolism by 20-Hydroxyecdysone in Antheraea pernyi (Lepidoptera: Saturniidae) During its Diapause Termination and Post-Termination Period.Journal of insect science (Online) · 2020Article
- Aminergic Signaling Controls Ovarian Dormancy in Drosophila.Scientific reports · 2018Article
- Physiological and molecular mechanisms underlying photoperiodism in the spider mite: comparisons with insects.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Review
- Review
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- Identification, functional characterization, and pharmacological profile of a serotonin type-2b receptor in the medically important insect, Rhodnius prolixus.Frontiers in neuroscience · 2015Article
- Structures and functions of insect arylalkylamine N-acetyltransferase (iaaNAT); a key enzyme for physiological and behavioral switch in arthropods.Frontiers in physiology · 2015Article
- N-acetyltransferase (nat) is a critical conjunct of photoperiodism between the circadian system and endocrine axis in Antheraea pernyi.PloS one · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
The release of prothoracicotropic hormone, PTTH, or its blockade is the major endocrine switch regulating the developmental channel either to metamorphosis or to pupal diapause in the Chinese silk moth, Antheraea pernyi. We have cloned cDNAs encoding two types of serotonin receptors (5HTRA and B). 5HTRA-, and 5HTRB-like immunohistochemical reactivities (-ir) were colocalized with PTTH-ir in two pairs of neurosecretory cells at the dorsolateral region of the protocerebrum (DL). Therefore, the causal involvement of these receptors was suspected in PTTH release/synthesis. The level of mRNA(5HTRB) responded to 10 cycles of long-day activation, falling to 40% of the original level before activation, while that of 5HTRA was not affected by long-day activation. Under LD 16:8 and 12:12, the injection of dsRNA(5HTRB) resulted in early diapause termination, whereas that of dsRNA(5HTRA) did not affect the rate of diapause termination. The injection of dsRNA(5HTRB) induced PTTH accumulation, indicating that 5HTRB binding suppresses PTTH synthesis also. This conclusion was supported pharmacologically; the injection of luzindole, a melatonin receptor antagonist, plus 5th inhibited photoperiodic activation under LD 16:8, while that of 5,7-DHT, induced emergence in a dose dependent fashion under LD 12:12. The results suggest that 5HTRB may lock the PTTH release/synthesis, maintaining diapause. This could also work as diapause induction mechanism.
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