ArticlePloS one2013
NMDA receptor antagonist ketamine impairs feature integration in visual perception.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Effects of psychotropic drugs on ocular parameters relevant to traffic safety: A systematic review.Neuroscience and biobehavioral reviews · 2022Pooled it
- A causal role of the NMDA receptor in recurrent processing during perceptual integration.eLife · 2025Trial
- The NMDA receptor partial agonist d-cycloserine does not enhance motor learning.Journal of psychopharmacology (Oxford, England) · 2016Trial
- A role beyond learning for NMDA receptors in reward-based decision-making-a pharmacological study using d-cycloserine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Effects of Expectation, Attention, and NMDA Receptor Blockade on Feedforward and Feedback Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Ketamine disrupts consciousness in healthy participants in relation with psychotic-like symptoms.bioRxiv : the preprint server for biology · 2025Article
- Resolving the Delusion Paradox.Schizophrenia bulletin · 2023Review
- Visual Functions Generating Conscious Seeing.Frontiers in psychology · 2020Article
- Challenges for theories of consciousness: seeing or knowing, the missing ingredient and how to deal with panpsychism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Development of Glutamatergic Proteins in Human Visual Cortex across the Lifespan.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Contributions of cortical feedback to sensory processing in primary visual cortex.Frontiers in psychology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recurrent interactions between neurons in the visual cortex are crucial for the integration of image elements into coherent objects, such as in figure-ground segregation of textured images. Blocking N-methyl-D-aspartate (NMDA) receptors in monkeys can abolish neural signals related to figure-ground segregation and feature integration. However, it is unknown whether this also affects perceptual integration itself. Therefore, we tested whether ketamine, a non-competitive NMDA receptor antagonist, reduces feature integration in humans. We administered a subanesthetic dose of ketamine to healthy subjects who performed a texture discrimination task in a placebo-controlled double blind within-subject design. We found that ketamine significantly impaired performance on the texture discrimination task compared to the placebo condition, while performance on a control fixation task was much less impaired. This effect is not merely due to task difficulty or a difference in sedation levels. We are the first to show a behavioral effect on feature integration by manipulating the NMDA receptor in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.