ArticlePloS one2013
Identification of new sphingomyelinases D in pathogenic fungi and other pathogenic organisms.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- How not to be seen: predicting unseen enzyme functions using contrastive learning.Bioinformatics (Oxford, England) · 2026Article
- Comparative genomic analysis of clinically relevant human skin-associated fungi.Nature communications · 2026Article
- How Not to be Seen: Predicting Unseen Enzyme Functions using Contrastive Learning.bioRxiv : the preprint server for biology · 2026Article
- Article
- An update on Glycerophosphodiester Phosphodiesterases; From Bacteria to Human.The protein journal · 2024Review
- A Brief Overview of the Toxic Sphingomyelinase Ds of Brown Recluse Spider Venom and Other Organisms and Simple Methods To Detect Production of Its Signature Cyclic Ceramide Phosphate.Molecular pharmacology · 2024Article
- Comparative Biochemical, Structural, and Functional Analysis of Recombinant Phospholipases D from ThreeInternational journal of molecular sciences · 2023Article
- Protein salvage and repurposing in evolution: Phospholipase D toxins are stabilized by a remodeled scrap of a membrane association domain.Protein science : a publication of the Protein Society · 2023Article
- Sphingomyelinase D Activity inToxins · 2021Article
- Loxoscelism: Advances and Challenges in the Design of Antibody Fragments with Therapeutic Potential.Toxins · 2020Article
- Tick-Borne Flavivirus Inhibits Sphingomyelinase (Frontiers in cellular and infection microbiology · 2020Article
- PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights.Brain : a journal of neurology · 2019Article
- Evolutionary dynamics of origin and loss in the deep history of phospholipase D toxin genes.BMC evolutionary biology · 2018Article
- Heterophilic antibodies in sera from individuals without loxoscelism cross-react with phospholipase D from the venom ofThe journal of venomous animals and toxins including tropical diseases · 2018Article
- Nano-LC-Q-TOF Analysis of Proteome Revealed Germination of Aspergillus flavus Conidia is Accompanied by MAPK Signalling and Cell Wall Modulation.Mycopathologia · 2016Article
- Bacterial Sphingomyelinases and Phospholipases as Virulence Factors.Microbiology and molecular biology reviews : MMBR · 2016Review
- Spider Bite: A Rare Case of Acute Necrotic Arachnidism with Rapid and Fatal Evolution.Case reports in emergency medicine · 2016Article
- Adaptive evolution in the toxicity of a spider's venom enzymes.BMC evolutionary biology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sphingomyelinases D (SMases D) or dermonecrotic toxins are well characterized in Loxosceles spider venoms and have been described in some strains of pathogenic microorganisms, such as Corynebacterium sp. After spider bites, the SMase D molecules cause skin necrosis and occasional severe systemic manifestations, such as acute renal failure. In this paper, we identified new SMase D amino acid sequences from various organisms belonging to 24 distinct genera, of which, 19 are new. These SMases D share a conserved active site and a C-terminal motif. We suggest that the C-terminal tail is responsible for stabilizing the entire internal structure of the SMase D Tim barrel and that it can be considered an SMase D hallmark in combination with the amino acid residues from the active site. Most of these enzyme sequences were discovered from fungi and the SMase D activity was experimentally confirmed in the fungus Aspergillus flavus. Because most of these novel SMases D are from organisms that are endowed with pathogenic properties similar to those evoked by these enzymes alone, they might be associated with their pathogenic mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.