ArticlePloS one2013
Topological progression in proliferating epithelia is driven by a unique variation in polygon distribution.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
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- Adhesion and Polarity protein distribution-regulates hexagon dominated plasma membrane organization in Drosophila blastoderm embryos.Genetics · 2023Article
- Tissues as networks of cells: towards generative rules of complex organ development.Journal of the Royal Society, Interface · 2023Review
- Geometric and network organization of visceral organ epithelium.Frontiers in network physiology · 2023Article
- Entropy as a Geometrical Source of Information in Biological Organizations.Entropy (Basel, Switzerland) · 2022Article
- The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization.Life science alliance · 2022Article
- EpiGraph: an open-source platform to quantify epithelial organization.Bioinformatics (Oxford, England) · 2020Article
- DeepScratch: Single-cell based topological metrics of scratch wound assays.Computational and structural biotechnology journal · 2020Article
- Rules of tissue packing involving different cell types: human muscle organization.Scientific reports · 2017Article
- Fundamental physical cellular constraints drive self-organization of tissues.The EMBO journal · 2016Article
- Fhl1 W122S causes loss of protein function and late-onset mild myopathy.Human molecular genetics · 2015Article
- Methodologies for analysis of patterning in the mouse RPE sheet.Molecular vision · 2015Article
- Biotensegrity of the extracellular matrix: physiology, dynamic mechanical balance, and implications in oncology and mechanotherapy.Frontiers in oncology · 2014Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphogenesis is consequence of lots of small coordinated variations that occur during development. In proliferating stages, tissue growth is coupled to changes in shape and organization. A number of studies have analyzed the topological properties of proliferating epithelia using the Drosophila wing disc as a model. These works are based in the existence of a fixed distribution of these epithelial cells according to their number of sides. Cell division, cell rearrangements or a combination of both mechanisms have been proposed to be responsible for this polygonal assembling. Here, we have used different system biology methods to compare images from two close proliferative stages that present high morphological similarity. This approach enables us to search for traces of epithelial organization. First, we show that geometrical and network characteristics of individual cells are mainly dependent on their number of sides. Second, we find a significant divergence between the distribution of polygons in epithelia from mid-third instar larva versus early prepupa. We show that this alteration propagates into changes in epithelial organization. Remarkably, only the variation in polygon distribution driven by morphogenesis leads to progression in epithelial organization. In addition, we identify the relevant features that characterize these rearrangements. Our results reveal signs of epithelial homogenization during the growing phase, before the planar cell polarity pathway leads to the hexagonal packing of the epithelium during pupal stages.
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