ArticlePloS one2013
Change of antibiotic susceptibility testing guidelines from CLSI to EUCAST: influence on cumulative hospital antibiograms.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Breakpoints for the Classification of Anti-BioMed research international · 2021Pooled it
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- Global in silico genomic epidemiology of tetracycline resistance in Staphylococcus aureus: one health dynamics and genotype-phenotype associations.Molecular genetics and genomics : MGG · 2026Article
- Septic arthritis and prosthetic joint infections: microbial spectrum and evolving resistance patterns.Journal of bone and joint infection · 2026Article
- Evaluating the Link Between Postoperative Timing of Rifampicin Introduction and the Clinical and Microbiological Outcomes of Orthopedic Staphylococcal Implant Infections.Antibiotics (Basel, Switzerland) · 2025Article
- The Performance of Gram-Staining in Tailoring the Empirical Antibiotic Choice in Operated Diabetic Foot Infections.Journal of clinical medicine · 2025Article
- Occurrence and Phenotypic Characteristics of Methicillin-ResistantJournal of clinical medicine · 2024Article
- Synthesis, characterization, and evaluation of antibacterial and antifungal activities of CuO-ZnO-CoHeliyon · 2024Article
- Antibiotic Resistance Pattern in Intensive Care Units in a Large Referral Hospital in Iran.Iranian journal of pathology · 2023Article
- Multi-Biofunctional Properties of Phytofabricated Selenium Nanoparticles FromFrontiers in microbiology · 2021Article
- The ecological effects of selective decontamination of the digestive tract (SDD) on antimicrobial resistance: a 21-year longitudinal single-centre study.Critical care (London, England) · 2019Observational
- Antibiotic resistance in Swiss nursing homes: analysis of National Surveillance Data over an 11-year period between 2007 and 2017.Antimicrobial resistance and infection control · 2018Article
- A new look at the drug-resistance investigation of uropathogenic E. coli strains.Molecular biology reports · 2017Article
- Colistin Resistance ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2017Article
- Antimicrobial Stewardship: How the Microbiology Laboratory Can Right the Ship.Clinical microbiology reviews · 2017Review
- Antibiogram of Medical Intensive Care Unit at Tertiary Care Hospital Setting of Pakistan.Cureus · 2016Article
- Comparison of Clinical Laboratory Standards Institute and European Committee on Antimicrobial Susceptibility Testing guidelines for the interpretation of antibiotic susceptibility at a University teaching hospital in Nairobi, Kenya: a cross-sectional study.Annals of clinical microbiology and antimicrobials · 2016Article
- Susceptibility of Austrian Clinical Klebsiella and Enterobacter Isolates Linked to Patient-Related Data.Frontiers in microbiology · 2016Article
- Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).World journal of emergency surgery : WJES · 2016Review
- Article
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6 authors.
Funding
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Abstract
objectiveWe studied whether the change in antibiotic susceptibility testing (AST) guidelines from CLSI to EUCAST influenced cumulative antibiograms in a tertiary care hospital in Switzerland.
methodsAntibiotic susceptibilities of non-duplicate isolates collected within a one-year period before (period A) and after (period B) changing AST interpretation from CLSI 2009 to EUCAST 1.3 (2011) guidelines were analysed. In addition, period B isolates were reinterpreted according to the CLSI 2009, CLSI 2013 and EUCAST 3.1 (2013) guidelines.
resultsThe majority of species/drug combinations showed no differences in susceptibility rates comparing periods A and B. However, in some gram-negative bacilli, decreased susceptibility rates were observed when comparing CLSI 2009 with EUCAST 1.3 within period B: Escherichia coli / cefepime, 95.8% (CLSI 2009) vs. 93.1% (EUCAST 1.3), P=0.005; Enterobacter cloacae / cefepime, 97.0 (CLSI 2009) vs. 90.5% (EUCAST 1.3), P=0.012; Pseudomonas aeruginosa / meropenem, 88.1% (CLSI 2009) vs. 78.3% (EUCAST 1.3), P=0.002. These differences were still evident when comparing susceptibility rates according to the CLSI 2013 guideline with EUCAST 3.1 guideline. For P. aeruginosa and imipenem, a trend towards a lower antibiotic susceptibility rate in ICUs compared to general wards turned into a significant difference after the change to EUCAST: 87.9% vs. 79.8%, P=0.08 (CLSI 2009) and 86.3% vs. 76.8%, P=0.048 (EUCAST 1.3).
conclusionsThe change of AST guidelines from CLSI to EUCAST led to a clinically relevant decrease of susceptibility rates in cumulative antibiograms for defined species/drug combinations, particularly in those with considerable differences in clinical susceptibility breakpoints between the two guidelines.
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