ArticlePloS one2013
RNA-Seq analysis reveals candidate genes for ontogenic resistance in Malus-Venturia pathosystem.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Transcriptomic responses to biotic stresses in Malus x domestica: a meta-analysis study.Scientific reports · 2018Pooled it
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- Comparative transcriptome and metabolite survey reveal key pathways involved in the control of the chilling injury disorder superficial scald in two apple cultivars, 'Granny Smith' and 'Ladina'.Frontiers in plant science · 2023Article
- Comparative transcriptomics unravels new genes imparting scab resistance in apple (Malus x domestica Borkh.).Functional & integrative genomics · 2022Article
- Integrated transcriptomic and transgenic analyses reveal potential mechanisms of poplar resistance to Alternaria alternata infection.BMC plant biology · 2022Article
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- Differential expression of genes in olive leaves and buds of ON- versus OFF-crop trees.Scientific reports · 2020Article
- Developmentally regulated activation of defense allows for rapid inhibition of infection in age-related resistance to Phytophthora capsici in cucumber fruit.BMC genomics · 2020Article
- Genome-Scale Characterization of Predicted Plastid-Targeted Proteomes in Higher Plants.Scientific reports · 2020Article
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- Transcriptome Analysis of Apple Leaves in Response to Powdery Mildew (International journal of molecular sciences · 2019Article
- Reference genes for gene expression studies targeting sugarcane infected with Sugarcane mosaic virus (SCMV).BMC research notes · 2019Article
- AppleMDO: A Multi-Dimensional Omics Database for Apple Co-Expression Networks and Chromatin States.Frontiers in plant science · 2019Article
- Transcriptome Profiles of Strawberry (Frontiers in plant science · 2019Article
- Transcriptome profiling of lentil (Lens culinaris) through the first 24 hours of Ascochyta lentis infection reveals key defence response genes.BMC genomics · 2018Article
- Identification of water use efficiency related genes in 'Garnem' almond-peach rootstock using time-course transcriptome analysis.PloS one · 2018Article
- Gaining Insight into Exclusive and Common Transcriptomic Features Linked with Biotic Stress Responses in Malus.Frontiers in plant science · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ontogenic scab resistance in apple leaves and fruits is a horizontal resistance against the plant pathogen Venturia inaequalis and is expressed as a decrease in disease symptoms and incidence with the ageing of the leaves. Several studies at the biochemical level tried to unveil the nature of this resistance; however, no conclusive results were reported. We decided therefore to investigate the genetic origin of this phenomenon by performing a full quantitative transcriptome sequencing and comparison of young (susceptible) and old (ontogenic resistant) leaves, infected or not with the pathogen. Two time points at 72 and 96 hours post-inoculation were chosen for RNA sampling and sequencing. Comparison between the different conditions (young and old leaves, inoculated or not) should allow the identification of differentially expressed genes which may represent different induced plant defence reactions leading to ontogenic resistance or may be the cause of a constitutive (uninoculated with the pathogen) shift toward resistance in old leaves. Differentially expressed genes were then characterised for their function by homology to A. thaliana and other plant genes, particularly looking for genes involved in pathways already suspected of appertaining to ontogenic resistance in apple or other hosts, or to plant defence mechanisms in general. IN THIS WORK, FIVE CANDIDATE GENES PUTATIVELY INVOLVED IN THE ONTOGENIC RESISTANCE OF APPLE WERE IDENTIFIED: a gene encoding an "enhanced disease susceptibility 1 protein" was found to be down-regulated in both uninoculated and inoculated old leaves at 96 hpi, while the other four genes encoding proteins (metallothionein3-like protein, lipoxygenase, lipid transfer protein, and a peroxidase 3) were found to be constitutively up-regulated in inoculated and uninoculated old leaves. The modulation of the five candidate genes has been validated using the real-time quantitative PCR. Thus, ontogenic resistance may be the result of the corresponding up- and down-regulation of these genes.
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