ArticlePloS one2013
Comprehensive analysis of single nucleotide polymorphisms in human microRNAs.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- miRNA gene mutations commonly disrupt the proper functioning of miRNA genes.Science advances · 2026Article
- Characterizing miRNA editing patterns in 5 types of cells using single-cell small RNA sequencing data.Frontiers in bioinformatics · 2026Article
- Profiling of the microRNA transcriptome in feline whole blood.Scientific reports · 2025Article
- Phenome-wide association study on miRNA-related sequence variants: the UK Biobank.Human genomics · 2023Article
- Identification of microRNA editing sites in clear cell renal cell carcinoma.Scientific reports · 2023Article
- Article
- Article
- A Single Variant in Pri-miRNA-155 Associated with Susceptibility to Hereditary Breast Cancer Promotes Aggressiveness in Breast Cancer Cells.International journal of molecular sciences · 2022Article
- Analysis of Homologous Regions of Small RNAsCells · 2022Article
- MiRLog and dbmiR: Prioritization and functional annotation tools to study human microRNA sequence variants.Human mutation · 2022Article
- Assessment of Association between miR-146a Polymorphisms and Expression of miR-146a, TRAF-6, and IRAK-1 Genes in Patients with Brucellosis.Molecular biology reports · 2022Article
- MicroRNA editing patterns in Huntington's disease.Scientific reports · 2022Article
- Identification of microRNA editing sites in three subtypes of leukemia.Frontiers in molecular biosciences · 2022Article
- Characterizing microRNA editing and mutation sites in Autism Spectrum Disorder.Frontiers in molecular neuroscience · 2022Article
- Consequences of genetic variants in miRNA genes.Computational and structural biotechnology journal · 2022Review
- A microRNA-microRNA crosstalk network inferred from genome-wide single nucleotide polymorphism variants in natural populations ofFrontiers in plant science · 2022Article
- Association analysis of miRNA-related genetic polymorphisms in miR-143/145 and KRAS with colorectal cancer susceptibility and survival.Bioscience reports · 2021Article
- Interleukin 27 Signaling in Rheumatoid Arthritis Patients: Good or Evil?Frontiers in immunology · 2021Review
- The Role ofCancers · 2020Review
- OPTIMIR, a novel algorithm for integrating available genome-wide genotype data into miRNA sequence alignment analysis.RNA (New York, N.Y.) · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are endogenous small non-coding RNAs that repress their targets at post transcriptional level. Single Nucleotide Polymorphisms (SNPs) in miRNAs can lead to severe defects to the functions of miRNAs and might result in diseases. Although several studies have tried to identify the SNPs in human miRNA genes or only in the mature miRNAs, there are only limited endeavors to explain the distribution of SNPs in these important genes. After a genome-wide scan for SNPs in human miRNAs, we totally identified 1899 SNPs in 961 out of the 1527 reported miRNA precursors of human, which is the most complete list of SNPs in human miRNAs to date. More importantly, to explain the distributions of SNPs existed in human miRNAs, we comprehensively and systematically analyzed the identified SNPs in miRNAs from several aspects. Our results suggest that conservation, genomic context, secondary structure, and functional importance of human miRNAs affect the accumulations of SNPs in these genes. Our results also show that the number of SNPs with significantly different frequencies among various populations in the HapMap and 1000 Genome Project data are consistent with the geographical distributions of these populations. These analyses provide a better insight of SNPs in human miRNAs and the spreading of the SNPs in miRNAs in different populations.
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