ArticlePloS one2013
Modeling the dynamics of bivalent histone modifications.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Mathematical modeling of histone modifications reveals the formation mechanism and function of bivalent chromatin.iScience · 2021Article
- Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent.Nature communications · 2019Article
- The Regulatory Capacity of Bivalent Genes-A Theoretical Approach.International journal of molecular sciences · 2017Article
- At the frontier of epigenetics of brain sex differences.Frontiers in behavioral neuroscience · 2015Review
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Authors and funding
5 authors.
Funding
Abstract
Epigenetic modifications to histones may promote either activation or repression of the transcription of nearby genes. Recent experimental studies show that the promoters of many lineage-control genes in stem cells have "bivalent domains" in which the nucleosomes contain both active (H3K4me3) and repressive (H3K27me3) marks. It is generally agreed that bivalent domains play an important role in stem cell differentiation, but the underlying mechanisms remain unclear. Here we formulate a mathematical model to investigate the dynamic properties of histone modification patterns. We then illustrate that our modeling framework can be used to capture key features of experimentally observed combinatorial chromatin states.
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