ArticlePloS one2013
Serum copeptin and cortisol do not accurately predict sickle cell anaemia vaso-occlusive crisis as C-reactive protein.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Cortisol in sickle cell disease: a systematic review and meta-analysis.Blood advances · 2025Pooled it
- Impaired phagocytosis and oxidative respiratory burst activity in sickle cell anemia leukocytes.Journal of Taibah University Medical Sciences · 2024Article
- Rare occurrence of type 2 diabetes mellitus in patients with sickle cell anaemia: assessing the contribution of inflammation, insulin resistance and glucose buffering capacity of abnormal haemoglobin.Journal of medical science · 2022Article
- Moving Toward a Multimodal Analgesic Regimen for Acute Sickle Cell Pain with Non-Opioid Analgesic Adjuncts: A Narrative Review.Journal of pain research · 2022Review
- Lower hair cortisol among patients with sickle cell disease may indicate decreased adrenal reserves.American journal of blood research · 2021Article
- Glucocorticoid receptor single nucleotide polymorphisms are associated with acute crisis pain in sickle cell disease.Pharmacogenomics · 2018Article
- Defective lipid metabolism in sickle cell anaemia subjects in vaso-occlusive crisis.Nigerian medical journal : journal of the Nigeria Medical Association · 2014Article
- Increased Circulating Copeptin Levels Are Associated with Vaso-Occlusive Crisis and Right Ventricular Dysfunction in Sickle Cell Anemia.Medical principles and practice : international journal of the Kuwait University, Health Science CentreArticle
- The Inflammatory Response to Surgery in Sickle Cell Disease Patients Undergoing Cholecystectomy.JSLS : Journal of the Society of Laparoendoscopic SurgeonsArticle
- Insulin Sensitivity, Inflammation, and Basal Metabolic Rate in Adults with Sickle Cell Anemia.International journal of applied & basic medical researchArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study assessed the diagnostic performance and prognostic properties of C-reactive protein (CRP), copeptin and cortisol in individuals with sickle cell anaemia (SCA).
designProspective case-control study.
methodsSixty consecutive SCA subjects (18-40 years) comprising 30 subjects in the steady state and 30 subjects in vaso-occlusive crisis (VOC) were recruited into this study. Thirty (30) apparently healthy individuals with HbAA genotype served as controls. ELISA was used for the determination of serum levels of copeptin, CRP and cortisol. Data obtained were statistically analyzed using the Student's t-test and Mann Whitney U as appropriate and P<0.05 was considered significant.
resultsSCA subjects in VOC had significantly lower copeptin level and significantly higher CRP level compared with controls. However, serum levels of copeptin, cortisol and CRP were significantly higher in SCA subjects in VOC compared with SCA subjects in steady state. Furthermore, CRP had the widest Area under the ROC curve (AUROC) than copeptin and cortisol. No significant difference was observed in the levels of copeptin, CRP and cortisol when SCA subjects in VOC who were hospitalized for less ≤ 5 days were compared with subjects who had longer stays.
conclusionIt could be concluded that C-reactive protein has a superior diagnostic performance for vaso-occlusive crisis in individuals with sickle cell anaemia and that C-reactive protein, cortisol and copeptin are not good prognostic markers in SCA subjects in vaso-occlusive crisis.
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