ArticleCardiovascular engineering and technology2013
Computational Fluid Dynamics Simulations of Hemodynamics in Plaque Erosion.
Article in Cardiovascular engineering and technology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03033810 (FFR Versus iFR in Assessment of Hemodynamic Lesion Significance Using Gene Polymorphisms and Lesion Morphology Assessed by OCT), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
FFR Versus iFR in Assessment of Hemodynamic Lesion Significance Using Gene Polymorphisms and Lesion Morphology Assessed by OCT (FiGARO Trial)
Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Role of biomechanical factors in plaque rupture and erosion: insight from intravascular imaging based computational modeling.NPJ cardiovascular health · 2025Review
- Comparison and identification of human coronary plaques with/without erosion using patient-specific optical coherence tomography-based fluid-structure interaction models: a pilot study.Biomechanics and modeling in mechanobiology · 2025Article
- Association of in situ thrombus within the patent foramen ovale and patients with migraine: A prospective cohort study.Heliyon · 2024Article
- Hemodynamics of vascular shunts: trends, challenges, and prospects.Biophysical reviews · 2023Review
- Application of physics-based flow models in cardiovascular medicine: Current practices and challenges.Biophysics reviews · 2021Review
- Plaque Erosion: A Distinctive Pathological Mechanism of Acute Coronary Syndrome.Frontiers in cardiovascular medicine · 2021Review
- Comparative Analysis of Three Different Optimization Procedures for Coronary Bifurcation Provisional Stenting: Insights from Micro-Computed Tomography and Optical Coherence Tomography Imaging of Bench Deployments.Acta Cardiologica Sinica · 2019Article
- Article
- High wall shear stress and high-risk plaque: an emerging concept.The international journal of cardiovascular imaging · 2017Review
- Optimal Revascularization Strategy on Medina 0,1,0 Left Main Bifurcation Lesions in Type 2 Diabetes.Journal of diabetes research · 2016Article
- Biomechanics and inflammation in atherosclerotic plaque erosion and plaque rupture: implications for cardiovascular events in women.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
purposeWe investigated whether local hemodynamics were associated with sites of plaque erosion and hypothesized that patients with plaque erosion have locally elevated WSS magnitude in regions where erosion has occurred.
methodsWe generated 3D, patient-specific models of coronary arteries from biplane angiographic images in 3 human patients with plaque erosion diagnosed by optical coherence tomography (OCT). Using computational fluid dynamics, we simulated pulsatile blood flow and calculated both wall shear stress (WSS) and oscillatory shear index (OSI). We also investigated anatomic features of plaque erosion sites by examining branching and local curvature in x-ray angiograms of barium-perfused autopsy hearts.
resultsNeither high nor low magnitudes of mean WSS were associated with sites of plaque erosion. OSI and local curvature were also not associated with erosion. Anatomically, 8 of 13 hearts had a nearby bifurcation upstream of the site of plaque erosion.
conclusionsThis study provides preliminary evidence that neither hemodynamics nor anatomy are predictors of plaque erosion, based upon a very unique dataset. Our sample sizes are small, but this dataset suggests that high magnitudes of wall shear stress, one potential mechanism for inducing plaque erosion, are not necessary for erosion to occur.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.