ArticleExperimental and therapeutic medicine2013
Characteristics of gastrointestinal symptoms and function following endoscopic submucosal dissection and treatment of the gastrointestinal symptoms using rikkunshito.
Article in Experimental and therapeutic medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Effects of colorectal endoscopic submucosal dissection on postoperative abdominal symptoms: a prospective observational study.Surgical endoscopy · 2022Observational
- Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor.Scientific reports · 2021Article
- Clinicopathological characteristics of patients with pain after endoscopic submucosal dissection for gastric epithelial neoplasm.Surgical endoscopy · 2019Article
- Endoscopic submucosal dissection for early gastric cancer on the lesser curvature in upper third of the stomach is a risk factor for postoperative delayed gastric emptying.Surgical endoscopy · 2018Article
- Predictive Factors for Pain After Endoscopic Resection of Gastric Tumors.Digestive diseases and sciences · 2016Observational
- Change in gastric emptying eight weeks after endoscopic submucosal dissection in patients with early gastric cancer.Endoscopy international open · 2016Article
- Keishibukuryogan, a Traditional Japanese Medicine, Inhibits Platelet Aggregation in Guinea Pig Whole Blood.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Clinical application of kampo medicine (rikkunshito) for common and/or intractable symptoms of the gastrointestinal tract.Frontiers in pharmacology · 2015Article
- Beneficial effects of rikkunshito, a Japanese kampo medicine, on gastrointestinal dysfunction and anorexia in combination with Western drug: a systematic review.Evidence-based complementary and alternative medicine : eCAM · 2014Review
- Rikkunshito, a ghrelin potentiator, ameliorates anorexia-cachexia syndrome.Frontiers in pharmacology · 2014Review
- Open Label Trial of the Efficacy and Safety Profile of Rikkunshito used for the Treatment of Gastrointestinal Symptoms in Patients with Parkinson's Disease: A Pilot Study.Current therapeutic research, clinical and experimentalArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to investigate the gastrointestinal (GI) symptoms and gastric emptying following endoscopic submucosal dissection (ESD), as well as to evaluate a novel treatment strategy using rikkunshito, a traditional Japanese herbal medicine. GI symptoms and gastric emptying were evaluated 6-8 days after ESD as part of the Step I study. In the Step 1 study, the Gastrointestinal Symptom Rating Scale (GSRS) scores of the two groups after 4 and 8 weeks of treatment with either a proton pump inhibitor (PPI; PPI monotreatment group, n=5) or a PPI plus rikkunshito (PPI + rikkunshito group, n=8) were compared against baseline values. Abdominal pain and constipation occurred in the majority of patients after ESD. The mean T-max 6-8 days after gastric emptying was 75.4±13.6 min, which was significantly longer compared with that reported in healthy subjects (43.9±10.3 min). In the Step 2 study, the total GSRS score was significantly improved only in the PPI + rikkunshito group after 8 weeks of treatment. In conclusion, ESD affects gastric emptying and is associated with an increased incidence of upper GI symptoms such as abdominal pain and indigestion. Rikkunshito may be useful as a novel supporting therapeutic drug for the treatment of GI symptoms in patients who have undergone ESD.
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