ReviewKorean journal of pediatrics2013
Clinical efficacy and mechanism of probiotics in allergic diseases.
Review in Korean journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 77 citations in OpenAlex.
- Efficacy ofNutrients · 2018Trial
- Immune dysregulation and gut microbiota: Connection to health and disease development.Neural regeneration research · 2026Article
- Paradoxical enrichment ofFrontiers in immunology · 2026Article
- Nutraceutical Intervention of Probiotics in Vision Science: A Systematic Review of Evolving Perspective.Journal of ophthalmology · 2026Review
- Unraveling the Pathogenesis of Asian Atopic Dermatitis: Key Characteristics and Insights.Annals of dermatology · 2025Review
- Adjuvant Effect ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Nutritional and Microbial Strategies for Treating Acne, Alopecia, and Atopic Dermatitis.Nutrients · 2024Review
- Review
- Probiotics and other adjuvants in allergen-specific immunotherapy for food allergy: a comprehensive review.Frontiers in allergy · 2024Review
- The causal relationship between gut microbiota and immune skin diseases: A bidirectional Mendelian randomization.PloS one · 2024Article
- Immunomodulatory effects of probiotic supplementation in patients with asthma: a randomized, double-blind, placebo-controlled trial.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- The causality between intestinal flora and allergic diseases: Insights from a bi-directional two-sample Mendelian randomization analysis.Frontiers in immunology · 2023Article
- Probiotics: Protecting Our Health from the Gut.Microorganisms · 2022Review
- Gut microbiota in various childhood disorders: Implication and indications.World journal of gastroenterology · 2022Review
- Article
- The Gut Microbiome: Human Health and Inflammatory Skin Diseases.Annals of dermatology · 2020Review
- Prebiotics and probiotics in atopic dermatitis.Experimental and therapeutic medicine · 2019Review
- Review
- Microbiota and Food Allergy.Clinical reviews in allergy & immunology · 2019Review
- Microbiome of the Skin and Gut in Atopic Dermatitis (AD): Understanding the Pathophysiology and Finding Novel Management Strategies.Journal of clinical medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A complex interplay between genetic and environmental factors partially contributes to the development of allergic diseases by affecting development during prenatal and early life. To explain the dramatic increase in the prevalence of allergic diseases, the hygiene hypothesis proposed that early exposure to infection prevented allergic diseases. The hygiene hypothesis has changed to the microbial hypothesis, in which exposure to microbes is closely linked to the development of the early immune system and allergic diseases. The intestinal flora may contribute to allergic disease through its substantial effect on mucosal immunity. Based on findings that exposure to microbial flora early in life can change the Th1/Th2 balance, thus favoring a Th1 cell response, probiotics may be beneficial in preventing allergic diseases. However, evidence from clinical and basic research to prove the efficacy of probiotics in preventing allergy is lacking. To date, studies have yielded inconsistent findings on the usefulness of probiotics in allergic diseases. It is difficult to demonstrate an exact effect of probiotics on asthma, allergic rhinitis, and food allergy because of study limitations, such as different first supplementation period, duration, different strains, short follow-up period, and host factors. However, many studies have demonstrated a significant clinical improvement in atopic dermatitis with the use of probiotics. An accurate understanding of the development of human immunity, intestinal barrier function, intestinal microbiota, and systemic immunity is required to comprehend the effects of probiotics on allergic diseases.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.