ArticleProstate international2013
Prostate-specific antigen and prostate-specific antigen density cutoff points among Indonesian population suspected for prostate cancer.
Article in Prostate international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis of the diagnostic accuracy of prostate-specific antigen (PSA) for the detection of prostate cancer in symptomatic patients.BMC medicine · 2022Pooled it
- Article
- PSMA PET/CT for prostate cancer diagnosis: current applications and future directions.Journal of cancer research and clinical oncology · 2025Review
- MRI-based habitat analysis of vascular and nerve invasion in the tumor microenvironment: an advanced approach for prostate cancer diagnosis.Frontiers in oncology · 2025Article
- Article
- Article
- Exosomes That Have Different Cellular Origins Followed by the Impact They Have on Prostate Tumor Development in the Tumor Microenvironment.Cancer reports (Hoboken, N.J.) · 2024Review
- Screening for prostate cancer in a city in Japan: age-specific prostate-specific antigen cutoff thresholds.Cancer causes & control : CCC · 2024Article
- Role of Exosomes in Prostate Cancer Metastasis.International journal of molecular sciences · 2021Review
- Relationship of age, prostate-specific antigen, and prostate volume in Indonesian men with benign prostatic hyperplasia.Prostate international · 2016Article
- Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- High mortality risk of prostate cancer patients in Asia and West Africa: A systematic review.Avicenna journal of medicineReview
- Metabolic syndrome in patients with prostate cancer undergoing intermittent androgen-deprivation therapy.Canadian Urological Association journal = Journal de l'Association des urologues du CanadaArticle
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6 authors.
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Abstract
purposeRacial differences exist in the incidence of prostate cancer (PCa). Although many studies have looked at the performance of prostate-specific antigen (PSA) and PSA density (PSAD) in the detection of PCa, only a few have looked at it in relation to Indonesian men. The objective of this study is to find out better PSA and PSAD cutoff point in the detection of PCa in Indonesian men.
methodsA total of 404 consecutive Indonesian men underwent prostate biopsy for suspicion of PCa from 2008 to 2011. The biopsy criteria include one or more of the following: serum PSA more than 10 ng/mL, PSAD more than 0.15 if PSA 4-10 ng/mL, hypoechoic lesion during transrectal sonography and/or abnormal digital rectal examination.
resultsForty five out of 404 (11.1%) had positive biopsies. The mean age, prostate volume, PSA and PSAD were respectively 64.06 years, 43.03 mL, 45.59 ng/mL and 1.15. Of the 404, 131 cases (32.4%) were confirmed to be urinary retention. Positive urine culture found in 182 cases (45%). The cutoff point to detect PCa as estimated by the receiver operating characteristics was 6.95 ng/mL for PSA (sensitivity 97.8%, specificity 19.6%) and 0.7072 for PSAD (sensitivity 62.2%, specificity 78.7%). Positive predictive value for this PSA and PSAD cutoff point were 11.6% and 27.5% respectively (P=0.004 and P=0.000). There was a significant correlation between hypoechoic lesion and positive biopsy results (P =0.000). Urinary retention elevates PSA cutoff point to 14.55 (sensitivity 90.9%, specificity 50%), while positive urine culture alters almost no PSA cutoff elevation.
conclusionsPSA and PSAD cutoff point for Indonesian men in this series is relatively different from international consensus. Furthermore, these data show that PSA and PSAD cutoff point must be adjusted to racial variation to discriminate between malignant and benign disease. Urinary retention is a significant factor for PSA cutoff increase.
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