ArticlePloS one2013
Intrinsic features in microRNA transcriptomes link porcine visceral rather than subcutaneous adipose tissues to metabolic risk.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Analyzing the transcriptomic diversity in isolated mature adipocytes from the major fat depots in rainbow trout (Oncorhynchus mykiss).BMC genomics · 2026Article
- Identification and characterization of microRNAs in the liver of yak (Bos grunniens) associated with energy deficiency at high-altitude.Animal bioscience · 2025Article
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- Tissue-specific responses of antioxidant pathways to poor hygiene conditions in growing pigs divergently selected for feed efficiency.BMC veterinary research · 2019Article
- An integrative transcriptomic approach to identify depot differences in genes and microRNAs in adipose tissues from high fat fed mice.Oncotarget · 2018Article
- miR-135a-5p affects adipogenic differentiation of human adipose-derived mesenchymal stem cellsby promoting the Hippo signaling pathway.International journal of clinical and experimental pathology · 2018Article
- Expression and Regulation Profile of Mature MicroRNA in the Pig: Relevance to Xenotransplantation.BioMed research international · 2018Review
- MicroRNA Transfer Between Bone Marrow Adipose and Multiple Myeloma Cells.Current osteoporosis reports · 2017Review
- miR-135b-5p regulates human mesenchymal stem cell osteogenic differentiation by facilitating the Hippo signaling pathway.International journal of clinical and experimental pathology · 2017Article
- The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling.Cell death and differentiation · 2016Article
- miR-148a is a downstream effector of X-box-binding protein 1 that silences Wnt10b during adipogenesis of 3T3-L1 cells.Experimental & molecular medicine · 2016Article
- Molecular alterations induced by a high-fat high-fiber diet in porcine adipose tissues: variations according to the anatomical fat location.BMC genomics · 2016Article
- miR-204-5p promotes the adipogenic differentiation of human adipose-derived mesenchymal stem cells by modulating DVL3 expression and suppressing Wnt/β-catenin signaling.International journal of molecular medicine · 2015Article
- Bias in microRNA functional enrichment analysis.Bioinformatics (Oxford, England) · 2015Article
- Gender and Obesity Specific MicroRNA Expression in Adipose Tissue from Lean and Obese Pigs.PloS one · 2015Article
- The miRNAome of the postpartum dairy cow liver in negative energy balance.BMC genomics · 2014Article
- MicroRNAs in bovine adipogenesis: genomic context, expression and function.BMC genomics · 2014Article
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12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are non-coding small RNA ∼22 nucleotides in length that can regulate the expression of a wide range of coding genes at the post-transcriptional level. Visceral adipose tissues (VATs) and subcutaneous adipose tissues (SATs), the two main fat compartments in mammals, are anatomically, physiologically, metabolically, and clinically distinct. Various studies of adipose tissues have focused mainly on DNA methylation, and mRNA and protein expression, nonetheless little research sheds directly light on the miRNA transcriptome differences between these two distinct adipose tissue types. Here, we present a comprehensive investigation of miRNA transcriptomes across six variant porcine adipose tissues by small RNA-sequencing. We identified 219 known porcine miRNAs, 97 novel miRNA*s, and 124 miRNAs that are conserved to other mammals. A set of universally abundant miRNAs (i.e., miR-148a-3p, miR-143-3p, miR-27b-3p, miR-let-7a-1-5p, and miR-let-7f-5p) across the distinct adipose tissues was found. This set of miRNAs may play important housekeeping roles that are involved in adipogenesis. Clustering analysis indicated significant variations in miRNA expression between the VATs and SATs, and highlighted the role of the greater omentum in responding to potential metabolic risk because of the observed enrichment in this tissue of the immune- and inflammation-related miRNAs, such as the members of miR-17-92 cluster and miR-181 family. Differential expression of the miRNAs between the VATs and SATs, and miRNA target prediction analysis revealed that the VATs-specific enriched miRNAs were associated mainly with immune and inflammation responses. In summary, the differences of miRNA expression between the VATs and SATs revealed some of their intrinsic differences and indicated that the VATs might be closely associated with increased risk of metabolic disorders.
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