ArticlePloS one2013
Personalized risk assessment of drug-related harm is associated with health outcomes.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Multilayer depressive symptom networks in adults with bodily pain living in precarious housing or homelessness.European archives of psychiatry and clinical neuroscience · 2024Article
- Article
- Component Processes of Decision Making in a Community Sample of Precariously Housed Persons: Associations With Learning and Memory, and Health-Risk Behaviors.Frontiers in psychology · 2021Article
- A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia.Psychopharmacology · 2019Observational
- Article
- The Hotel Study-Clinical and Health Service Effectiveness in a Cohort of Homeless or Marginally Housed Persons.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Article
- A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence.Psychopharmacology · 2017Article
- Article
- White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection.BMC research notes · 2015Article
- Mortality from treatable illnesses in marginally housed adults: a prospective cohort study.BMJ open · 2015Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundThe Independent Scientific Committee on Drugs (ISCD) assigned quantitative scores for harm to 20 drugs. We hypothesized that a personalized, ISCD-based Composite Harm Score (CHS) would be associated with poor health outcomes in polysubstance users.
methodsA prospective community sample (n=293) of adults living in marginal housing was assessed for substance use. The CHS was calculated based on the ISCD index, and the personal substance use characteristics over four weeks. Regression models estimated the association between CHS and physical, psychological, and social health outcomes.
resultsPolysubstance use was pervasive (95.8%), as was multimorbid illness (median 3, possible range 0-12). The median CHS was 2845 (interquartile range 1865-3977). Adjusting for age and sex, every 1000-unit CHS increase was associated with greater mortality (odds ratio [OR] 1.47, 95% confidence interval [CI] 1.07-2.01, p = 0.02), and persistent hepatitis C infection (OR 1.29, 95% CI 1.02-1.67, p = 0.04). The likelihood of substance-induced psychosis increased 1.39-fold (95% CI 1.13-1.67, p = 0.001). The amount spent on drugs increased 1.51-fold (1.40-1.62, p < 0.001) and the odds of having committed a crime increased 1.74-fold (1.46-2.10, p < 0.001). Multimorbid illness increased 1.43-fold (95% CI 1.26-1.63, p < 0.001).
conclusionsGreater CHS predicts poorer physical, psychological, and social health, and may be a useful quantitative, personalized measure of risk for drug-related harm.
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