ArticlePloS one2013
Depth-dependent differences in community structure of the human colonic microbiota in health.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Colonisation of the colonic mucus gel layer with butyrogenic and hydrogenotropic bacteria in health and ulcerative colitis.Scientific reports · 2021Trial
- Intestinal Microbiota and Fecal Transplantation in Patients with Inflammatory Bowel Disease andJournal of clinical medicine · 2025Review
- Altered mucosal bacteria and metabolomics in patients with Peutz-Jeghers syndrome.Gut pathogens · 2024Article
- Pilot Study: Safety and Performance Validation of an Ingestible Medical Device for Collecting Small Intestinal Liquid in Healthy Volunteers.Methods and protocols · 2024Article
- Effects of Bifidobacterium BL21 and Lacticaseibacillus LRa05 on gut microbiota in type 2 diabetes mellitus mice.AMB Express · 2023Article
- Gut Microbiome in Patients after Heart Transplantation-Current State of Knowledge.Biomedicines · 2023Review
- Isolation and Cultivation of Human Gut Microorganisms: A Review.Microorganisms · 2023Review
- Phylogenetic analysis of Arthrospira strains from Ordos based on 16S rRNA.Scientific reports · 2022Article
- Article
- Technological tools and strategies for culturing human gut microbiota in engineered in vitro models.Biotechnology and bioengineering · 2021Review
- Current Sampling Methods for Gut Microbiota: A Call for More Precise Devices.Frontiers in cellular and infection microbiology · 2020Review
- Polysaccharide from wild morels alters the spatial structure of gut microbiota and the production of short-chain fatty acids in mice.Bioscience of microbiota, food and health · 2020Article
- The abundance of Akkermansia muciniphila and its relationship with sulphated colonic mucins in health and ulcerative colitis.Scientific reports · 2019Article
- Analysis of the colonic mucosa associated microbiota (MAM) using brushing samples during colonic endoscopic procedures.Journal of clinical biochemistry and nutrition · 2019Article
- Festschrift for Ronan O'Connell: pouchitis, ulcerative colitis and the microbiome.Irish journal of medical science · 2018Review
- Sampling Strategies for Three-Dimensional Spatial Community Structures in IBD Microbiota Research.Frontiers in cellular and infection microbiology · 2017Review
- Human colorectal mucosal microbiota correlates with its host niche physiology revealed by endomicroscopy.Scientific reports · 2016Article
- Article
- Lentinula edodes-derived polysaccharide alters the spatial structure of gut microbiota in mice.PloS one · 2015Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aims of this study were to develop techniques for spatial microbial assessment in humans and to establish colonic luminal and mucosal spatial ecology, encompassing longitudinal and cross-sectional axes.
designA microbiological protected specimen brush was used in conjunction with a biopsy forceps to sample the colon in nine healthy volunteers undergoing colonoscopy. Terminal Restriction Fragment Length Polymorphism analysis was used to determine the major variables in the spatial organization of the colonic microbiota.
resultsProtected Specimen Brush sampling retrieved region-specific, uncontaminated samples that were enriched for bacterial DNA and depleted in human DNA when compared to biopsy samples. Terminal Restriction Fragment Length Polymorphism analysis revealed a segmentation of bacterial communities between the luminal brush and biopsy-associated ecological niches with little variability across the longitudinal axis of the colon and reduced diversity in brush samples.
conclusionThese results support the concept of a microbiota with little longitudinal variability but with some degree of segregation between luminal and mucosal communities.
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Registered trials
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