ArticleWorld journal of gastroenterology2013
Photodynamic therapy vs radiofrequency ablation for Barrett's dysplasia: efficacy, safety and cost-comparison.
Article in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Review
- Endoscopic Management of Strictures in Crohn's Disease: An Unsolved Case.Journal of clinical medicine · 2024Review
- Review
- Pulsed Electric Field Ablation of Esophageal Malignancies and Mitigating Damage to Smooth Muscle: An In Vitro Study.International journal of molecular sciences · 2023Article
- Review
- Advancements in photodynamic therapy of esophageal cancer.Frontiers in oncology · 2022Review
- Endoscopic therapies for Barrett's esophagus.Translational gastroenterology and hepatology · 2021Review
- Feasibility study of endoscopic thermal coagulation with circumferential laser irradiation for treating esophageal tissue.Lasers in medical science · 2020Article
- Endoscopic management of esophageal cancer.World journal of gastrointestinal oncology · 2019Review
- Endoscopic therapy for confirmed low-grade dysplasia in Barrett's esophagus.Translational gastroenterology and hepatology · 2018Review
- Radiofrequency ablation devices.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2017Article
- Recurrence of intestinal metaplasia and early neoplasia after endoscopic eradication therapy for Barrett's esophagus: a systematic review and meta-analysis.Endoscopy international open · 2017Article
- Barrett's esophagus: diagnosis and management.Gastrointestinal endoscopy · 2017Review
- Recurrence of Barrett's Esophagus is Rare Following Endoscopic Eradication Therapy Coupled With Effective Reflux Control.The American journal of gastroenterology · 2017Observational
- Barrett's esophagus: best practices for treatment and post-treatment surveillance.Annals of cardiothoracic surgery · 2017Review
- Outcomes of Radiofrequency Ablation for Dysplastic Barrett's Esophagus: A Comprehensive Review.Gastroenterology research and practice · 2016Review
- Endoscopic resection of gastric and esophageal cancer.Gastroenterology report · 2015Review
- Treatment of esophagogastric junction carcinoma: an unsolved debate.World journal of gastroenterology · 2015Review
- Esophageal papilloma: Flexible endoscopic ablation by radiofrequency.World journal of gastrointestinal endoscopy · 2015Article
- Endoscopic treatments for dysplastic Barrett's esophagus: resection, ablation, what else?World journal of surgery · 2015Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo compare effectiveness, safety, and cost of photodynamic therapy (PDT) and radiofrequency ablation (RFA) in treatment of Barrett's dysplasia (BD).
methodsConsecutive case series of patients undergoing either PDT or RFA treatment at single center by a single investigator were compared. Thirty-three patients with high-grade dysplasia (HGD) had treatment with porfimer sodium photosensitzer and 630 nm laser (130 J/cm), with maximum of 3 treatment sessions. Fifty-three patients with BD (47 with low-grade dysplasia -LGD, 6 with HGD) had step-wise circumferential and focal ablation using the HALO system with maximum of 4 treatment sessions. Both groups received proton pump inhibitors twice daily. Endoscopic biopsies were acquired at 2 and 12 mo after enrollment, with 4-quadrant biopsies every 1 cm of the original BE extent. A complete histological resolution response of BD (CR-D) was defined as all biopsies at the last endoscopy session negative for BD. Fisher's exact test was used to assess differences between the two study groups for primary outcomes. For all outcomes, a two-sided P value of less than 0.05 was considered to indicate statistical significance.
resultsThirty (91%) PDT patients and 39 (74%) RFA were men (P = 0.05). The mean age was 70.7 ± 12.2 and 65.4 ± 12.7 (P = 0.10) year and mean length of BE was 5.4 ± 3.2 cm and 5.7 ± 3.2 cm (P = 0.53) for PDT and RFA patients, respectively. The CR-D was (18/33) 54.5% with PDT vs (47/53) 88.7% with RFA (P = 0.001). One patient with PDT had an esophageal perforation and was managed with non-surgical measures and no perforation was seen with RFA. PDT was five times more costly than RFA at our institution. The two groups were not randomized and had different BD grading are the limitations of the study.
conclusionIn our experience, RFA had higher rate of CR-D without any serious adverse events and was less costly than PDT for endoscopic treatment of BD.
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