ArticleBioMed research international2013
Ovarian and breast cancer spheres are similar in transcriptomic features and sensitive to fenretinide.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-Analysis of Tumor Stem-Like Breast Cancer Cells Using Gene Set and Network Analysis.PloS one · 2016Pooled it
- Fenretinide in cancer therapy and chemoprevention: past, present and future.Cancer drug resistance (Alhambra, Calif.) · 2026Review
- Mg alloys with antitumor and anticorrosion properties for orthopedic oncology: A review from mechanisms to application strategies.APL bioengineering · 2024Review
- VLDLR disturbs quiescence of breast cancer stem cells in a ligand-independent function.Frontiers in oncology · 2022Article
- The Enrichment of Breast Cancer Stem Cells from MCF7 Breast Cancer Cell Line Using Spheroid Culture Technique.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Targeting Sphingolipids for Cancer Therapy.Frontiers in oncology · 2021Review
- An Integrative Computational Approach Based on Expression Similarity Signatures to Identify Protein-Protein Interaction Networks in Female-Specific Cancers.Frontiers in genetics · 2020Article
- PRSS1 Upregulation Predicts Platinum Resistance in Ovarian Cancer Patients.Frontiers in cell and developmental biology · 2020Article
- Interleukin 6 signaling maintains the stem-like properties of bladder cancer stem cells.Translational cancer research · 2019Article
- Mammary Stem Cells in Domestic Animals: The Role of ROS.Antioxidants (Basel, Switzerland) · 2018Review
- Fenretinide targeting of human colon cancer sphere cells through cell cycle regulation and stress-responsive activities.Oncology letters · 2018Article
- Cells with stemness features are generated from in vitro transformed human fibroblasts.Scientific reports · 2018Article
- Are breast cancer stem cells the key to resolving clinical issues in breast cancer therapy?Gland surgery · 2017Review
- Article
- Evaluation of stem cell properties in human ovarian carcinoma cells using multi and single cell-based spheres assays.Journal of visualized experiments : JoVE · 2015Article
- Cancer Stem and Progenitor-Like Cells as Pharmacological Targets in Breast Cancer Treatment.Breast cancer : basic and clinical research · 2015Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer stem cells (CSCs) are resistant to chemotherapy and are ability to regenerate cancer cell populations, thus attracting much attention in cancer research. In this report, we first demonstrated that sphere cells from ovarian cancer cell line A2780 shared many features of CSCs, such as resistance to cisplatin and able to initiate tumors in an efficient manner. Then, we conducted cDNA microarray analysis on spheres from ovarian A2780 cells, and from breast MCF7 and SUM159 cells, and found that molecular pathways underlying spheres from these cancer cell lines were similar to a large extent, suggesting that similar mechanisms are involved in the genesis of CSCs in both ovarian and breast cancer types. In addition, we showed that spheres from these cancer types were highly sensitive to fenretinide, a stimulus of oxidative stress-mediated apoptosis in cancer cells. Thus, our results not only provide important insights into mechanisms underlying CSCs in ovarian and breast cancer, but also lead to the development of more sophisticated protocols of cancer therapy in near future.
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