Evidence map›Paper›PMID 24222477›Full record

SynthesisPharmacoEconomics2013

Cost effectiveness of medication adherence-enhancing interventions: a systematic review of trial-based economic evaluations.

Edwin J M Oberjé, Reina J A de Kinderen, Silvia M A A Evers, Cees M J van Woerkum, Marijn de Bruin

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in PharmacoEconomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03331978 (A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans), which is not on this map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03331978 nacompletednot on this mapstarted 2018, after this paper: background citation

A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans

TypeinterventionalSponsorRANDRan2018 to 2021Enrolled306ConditionsHIV/AIDSArmsRise - Treatment Education
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
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  4. Interventions for enhancing medication adherence.The Cochrane database of systematic reviews · 2014
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  11. Improving Adherence to Cardiovascular Therapies: An Economic Evaluation of a Randomized Pragmatic Trial.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Edwin J M OberjéDepartment of Communication Science, Amsterdam School of Communication Research (ASCoR), University of Amsterdam, Kloveniersburgwal 48, 1012 CX, Amsterdam, The Netherlands, e.j.m.oberje@uva.nl.
Reina J A de Kinderen
Silvia M A A Evers
Cees M J van Woerkum
Marijn de Bruin
Maastricht University · NLUniversity of Aberdeen · GBUniversity of Amsterdam · NLWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn light of the pressure to reduce unnecessary healthcare expenditure in the current economic climate, a systematic review that assesses evidence of cost effectiveness of adherence-enhancing interventions would be timely.

objectiveOur objective was to examine the cost effectiveness of adherence-enhancing interventions compared with care as usual in randomised controlled trials, and to assess the methodological quality of economic evaluations.

methodsMEDLINE, PsycInfo, EconLit and the Centre for Reviews and Dissemination databases were searched for randomised controlled trials reporting full economic evaluations of adherence-enhancing interventions (published up to June 2013). Information was collected on study characteristics, cost effectiveness of treatment alternatives, and methodological quality.

resultsA total of 14 randomised controlled trials were included. The quality of economic evaluations and the risk of bias varied considerably between trials. Four studies showed incremental cost-effectiveness ratios (ICERs) below the willingness-to-pay threshold. Few studies seemed to evaluate interventions that successfully changed adherence.

conclusionsOnly 14 randomised controlled trials examined the cost effectiveness of adherence interventions. Despite that some studies showe favourable ICERs, the overall quality of studies was modest and the economic perspectives applied were frequently narrow. To demonstrate that adherence interventions can be cost effective, we recommend that proven-effective adherence programmes are subjected to comprehensive economic evaluations.

Indexed as

Patient ComplianceCost-Benefit AnalysisDatabases, BibliographicHealth PromotionHumansQuality-Adjusted Life YearsRandomized Controlled Trials as Topic

Identifiers

PMID24222477
OpenAlexW1982007038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.