ArticleJournal of cachexia, sarcopenia and muscle2014
Hypothalamic food intake regulation in a cancer-cachectic mouse model.
Article in Journal of cachexia, sarcopenia and muscle, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Comprehensive insights into emerging advances in the Neurobiology of anorexia.Journal of advanced research · 2026Review
- Prognostic impact of the cross-sectional area of the erector spinae muscle in patients with pleuroparenchymal fibroelastosis.Scientific reports · 2023Article
- Effects of whole-body vibration training in a cachectic C26 mouse model.Scientific reports · 2021Article
- The Use of Proton Pump Inhibitors May Increase Symptoms of Muscle Function Loss in Patients with Chronic Illnesses.International journal of molecular sciences · 2020Review
- Reliability of blood lactate as a measure of exercise intensity in different strains of mice during forced treadmill running.PloS one · 2019Article
- Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia.Journal of cachexia, sarcopenia and muscle · 2017Article
- Hypothesis: solid tumours behave as systemic metabolic dictators.Journal of cellular and molecular medicine · 2016Article
- Increased hypothalamic serotonin turnover in inflammation-induced anorexia.BMC neuroscience · 2016Article
- Nutrition in cachexia: from bench to bedside.Journal of cachexia, sarcopenia and muscle · 2016Article
- Pathophysiology of anorexia in the cancer cachexia syndrome.Journal of cachexia, sarcopenia and muscle · 2015Review
- Behavioural changes are a major contributing factor in the reduction of sarcopenia in caloric-restricted ageing mice.Journal of cachexia, sarcopenia and muscle · 2015Article
- Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue.Physiology & behavior · 2015Article
- Differences in food intake of tumour-bearing cachectic mice are associated with hypothalamic serotonin signalling.Journal of cachexia, sarcopenia and muscle · 2015Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAppetite is frequently affected in cancer patients leading to anorexia and consequently insufficient food intake. In this study, we report on hypothalamic gene expression profile of a cancer-cachectic mouse model with increased food intake. In this model, mice bearing C26 tumour have an increased food intake subsequently to the loss of body weight. We hypothesise that in this model, appetite-regulating systems in the hypothalamus, which apparently fail in anorexia, are still able to adapt adequately to changes in energy balance. Therefore, studying changes that occur on appetite regulators in the hypothalamus might reveal targets for treatment of cancer-induced eating disorders. By applying transcriptomics, many appetite-regulating systems in the hypothalamus could be taken into account, providing an overview of changes that occur in the hypothalamus during tumour growth.
methodsC26-colon adenocarcinoma cells were subcutaneously inoculated in 6 weeks old male CDF1 mice. Body weight and food intake were measured three times a week. On day 20, hypothalamus was dissected and used for transcriptomics using Affymetrix chips.
resultsFood intake increased significantly in cachectic tumour-bearing mice (TB), synchronously to the loss of body weight. Hypothalamic gene expression of orexigenic neuropeptides NPY and AgRP was higher, whereas expression of anorexigenic genes CCK and POMC were lower in TB compared to controls. In addition, serotonin and dopamine signalling pathways were found to be significantly altered in TB mice. Serotonin levels in brain showed to be lower in TB mice compared to control mice, while dopamine levels did not change. Moreover, serotonin levels inversely correlated with food intake.
conclusionsTranscriptomic analysis of the hypothalamus of cachectic TB mice with an increased food intake showed changes in NPY, AgRP and serotonin signalling. Serotonin levels in the brain showed to correlate with changes in food intake. Further research has to reveal whether targeting these systems will be a good strategy to avoid the development of cancer-induced eating disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.