ArticleDiabetes2014
T-cell costimulation protects obesity-induced adipose inflammation and insulin resistance.
Article in Diabetes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 68 citations in OpenAlex.
- Adipocyte OX40L promotes adipose T cell activation and insulin resistance in obesity.Experimental & molecular medicine · 2026Article
- Placental gene signatures associated with high neonatal adiposity: role for immune cell activation.Journal of the Endocrine Society · 2026Article
- Tissue-specific roles of regulatory T cells: mechanisms of suppression and beyond along with emerging therapeutic insights in autoimmune indications.Frontiers in immunology · 2025Review
- Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic health.Immunological reviews · 2024Review
- Adipose-tissue regulatory T cells are a consortium of subtypes that evolves with age and diet.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Adipose tissue lymphocytes and obesity.The journal of cardiovascular aging · 2024Article
- Obese visceral adipose dendritic cells downregulate regulatory T cell development through IL-33.Frontiers in immunology · 2024Article
- Obesity aggravates contact hypersensitivity reaction in mice.Contact dermatitis · 2022Article
- Review
- Tissue regulatory T cells: regulatory chameleons.Nature reviews. Immunology · 2021Review
- Adipose Tissue Dendritic Cells: Critical Regulators of Obesity-Induced Inflammation and Insulin Resistance.International journal of molecular sciences · 2021Review
- Oestrogen receptor α in T cells controls the T cell immune profile and glucose metabolism in mouse models of gestational diabetes mellitus.Diabetologia · 2021Article
- Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity.Children (Basel, Switzerland) · 2021Review
- Adipose Tissue T Regulatory Cells: Implications for Health and Disease.Advances in experimental medicine and biology · 2021Article
- High-fat diet-induced obesity affects alpha 7 nicotine acetylcholine receptor expressions in mouse lung myeloid cells.Scientific reports · 2020Article
- Metabolic Inflammation and Insulin Resistance in Obesity.Circulation research · 2020Review
- B Lymphocytes and Adipose Tissue Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- miR-223-3p Inhibits Antigen Endocytosis and Presentation and Promotes the Tolerogenic Potential of Dendritic Cells through Targeting Mannose Receptor Signaling and Rhob.Journal of immunology research · 2020Article
- Obesity-induced inflammation and insulin resistance: A mini-review on T-cells.Metabolism open · 2019Article
- Inflammation and Immunity: From an Adipocyte's Perspective.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2019Review
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
A key pathophysiologic role for activated T-cells in mediating adipose inflammation and insulin resistance (IR) has been recently postulated. However, mechanisms underlying their activation are poorly understood. In this study, we demonstrated a previously unrecognized homeostatic role for the costimulatory B7 molecules (CD80 and CD86) in preventing adipose inflammation. Instead of promoting inflammation, which was found in many other disease conditions, B7 costimulation reduced adipose inflammation by maintaining regulatory T-cell (Treg) numbers in adipose tissue. In both humans and mice, expression of CD80 and CD86 was negatively correlated with the degree of IR and adipose tissue macrophage infiltration. Decreased B7 expression in obesity appeared to directly impair Treg proliferation and function that lead to excessive proinflammatory macrophages and the development of IR. CD80/CD86 double knockout (B7 KO) mice had enhanced adipose macrophage inflammation and IR under both high-fat and normal diet conditions, accompanied by reduced Treg development and proliferation. Adoptive transfer of Tregs reversed IR and adipose inflammation in B7 KO mice. Our results suggest an essential role for B7 in maintaining Tregs and adipose homeostasis and may have important implications for therapies that target costimulation in type 2 diabetes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.