ArticleCell stress & chaperones2014
Vitamin D receptor-modulated Hsp70/AT1 expression may protect the kidneys of SHRs at the structural and functional levels.
Article in Cell stress & chaperones, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Vitamin D ameliorates celecoxib cardiotoxicity in a doxorubicin heart failure rat model via enhancement of the antioxidant defense and minimizing mitochondrial dysfunction.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Vitamin D in Type 2 Diabetes and Its Correlation With Heat Shock Protein 70, Ferric Reducing Ability of Plasma, Advanced Oxidation Protein Products and Advanced Glycation End Products.Endocrinology, diabetes & metabolism · 2024Article
- Genomic or Non-Genomic? A Question about the Pleiotropic Roles of Vitamin D in Inflammatory-Based Diseases.Nutrients · 2023Review
- The Perspective of Vitamin D on suPAR-Related AKI in COVID-19.International journal of molecular sciences · 2022Review
- Article
- Vitamin D Deficiency and Risk of Metabolic Syndrome in Aging Men.The world journal of men's health · 2021Review
- Vitamin D and Glomerulonephritis.Medicina (Kaunas, Lithuania) · 2021Review
- Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D.Antioxidants (Basel, Switzerland) · 2020Review
- Vitamin D as A Protector of Arterial Health: Potential Role in Peripheral Arterial Disease Formation.International journal of molecular sciences · 2019Review
- Article
- Vitamin D and calcium kidney stones: a review and a proposal.International urology and nephrology · 2019Review
- Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension.Current hypertension reports · 2018Review
- Vitamin D Receptor: A Novel Therapeutic Target for Kidney Diseases.Current medicinal chemistry · 2018Review
- Growing evidence suggests WT1 effects in the kidney development are modulated by Hsp70/NO interaction.Journal of nephrology · 2017Review
- The protective role of vitamin D on the heart and the kidney.Therapeutic advances in cardiovascular disease · 2017Review
- Superoxide increases angiotensin II AT1 receptor function in human kidney-2 cells.FEBS open bio · 2016Article
- Changes in renal WT-1 expression preceding hypertension development.BMC nephrology · 2016Article
- Emerging Role of Nitric Oxide and Heat Shock Proteins in Insulin Resistance.Current hypertension reports · 2016Review
- Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy.Cell stress & chaperones · 2015Review
- Hypertension and insulin resistance: implications of mitochondrial dysfunction.Current hypertension reports · 2015Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Previous hypertension studies have shown that low levels of vitamin D are linked to elevated renin-angiotensin system. The heat shock protein 70 regulates signaling pathways for cellular oxidative stress responses. Hsp70 has been shown to protect against angiotensin II-induced hypertension and exert a cytoprotective effect. Here, we wanted to evaluate whether the vitamin D receptor (VDR) associated with Hsp70/AT1 expression may be involved in the mechanism by which paricalcitol provides renal protection in spontaneously hypertensive rats (SHRs). One-month-old female SHRs were treated for 4 months with vehicle, paricalcitol, enalapril, or a combination of both paricalcitol and enalapril. The following were determined: blood pressure; biochemical parameters; fibrosis; apoptosis; mitochondrial morphology; and VDR, AT1 receptor, and Hsp70 expression in the renal cortex. Blood pressure was markedly reduced by enalapril or the combination but not by paricalcitol alone. However, VDR activation, enalapril or combination, prevented fibrosis, the number of TUNEL-positive apoptotic cells, mitochondrial damage, and NADPH oxidase activity in SHRs. Additionally, high AT1 receptor expression, like low Hsp70 expression (immunohistochemical/immunofluorescence studies), was reversed in the renal cortices of paricalcitol- and/or enalapril-treated animals (SHRs), and these changes were most marked in the combination therapy group. Finally, all of the recovery parameters were consistent with an improvement in VDR expression. Data suggest that Hsp70/AT1 modulated by VDR is involved in the mechanism by which paricalcitol provides renal protection in SHRs. We propose that low AT1 expression through VDR induction could be a consequence of the heat shock response Hsp70-mediated cell protection.
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