Evidence map›Paper›PMID 24222025›Full record

ArticleAngewandte Chemie (International ed. in English)2013

Enzymatic "click" ligation: selective cysteine modification in polypeptides enabled by promiscuous glutathione S-transferase.

Chi Zhang, Alexander M Spokoyny, Yekui Zou, Mark D Simon, Bradley L Pentelute

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Peptide Tags for Site-Selective Nonenzymatic Covalent Modification of Proteins.Journal of peptide science : an official publication of the European Peptide Society · 2025
    Review
  4. Article
  5. Article
  6. Site-selectiveChemical science · 2024
    Article
  7. Review
  8. Review
  9. Review
  10. Arylation Chemistry for Bioconjugation.Angewandte Chemie (International ed. in English) · 2019
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chi ZhangDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MA 02139 (USA).
Alexander M Spokoyny
Yekui Zou
Mark D Simon
Bradley L Pentelute

Funding

CATALYTIC METHODS FOR ORGANIC SYNTHESISR37GM046059 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BUCHWALD, STEPHEN L · 2000 to 2009
$8.1M
EARLY TRANSITION METAL CATALYSTS IN ORGANIC SYNTHESISR01GM046059 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BUCHWALD, STEPHEN L · 1992 to 2016
$5.4M
Metal Catalyzed CN and CS Bond Forming Reactions for Bioconjugation TargetsF32GM101762 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SPOKOYNY, ALEXANDER MICHAEL · 2012 to 2013
$96k
NIGMS NIH HHS F32 GM101762NIGMS NIH HHS GM046059NIGMS NIH HHS GM101762NIGMS NIH HHS R01 GM046059NIGMS NIH HHS R37 GM046059
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CatalysisClick ChemistryCysteineGlutathione TransferaseHumansPeptidesProtein Processing, Post-TranslationalCysteineGlutathione TransferasePeptidesbioconjugationclick chemistrycysteine arylationenzyme catalysispeptide macrocyclization

Identifiers

PMID24222025
PMCPMC3935385

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.