SynthesisJournal of assisted reproduction and genetics2014
Apolipoprotein E (Apo E) gene polymorphisms and recurrent pregnancy loss: a meta-analysis.
Synthesis in Journal of assisted reproduction and genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank.EBioMedicine · 2020Pooled it
- Genetic association between FXIII and β-fibrinogen genes and women with recurrent spontaneous abortion: a meta- analysis.Journal of assisted reproduction and genetics · 2015Pooled it
- Pregnancy and breastfeeding are associated with less later-life cognitive decline in a longitudinal, prospective cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Apolipoprotein E polymorphisms and female fertility in a transgenic mouse model of Alzheimer's disease.Scientific reports · 2024Article
- Maternal Thrombophilic and Hypofibrinolytic Genetic Variants in Idiopathic Recurrent Pregnancy Loss: a Continuing Mystery.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Identification of genetic alterations in couples and their products of conceptions from recurrent pregnancy loss in North Indian population.Frontiers in genetics · 2023Article
- Role ofInternational journal of reproductive biomedicine · 2022Article
- apoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetes.BMJ open diabetes research & care · 2021Article
- The lncRNAJournal of inflammation research · 2021Article
- Pregnancy loss and risk of later dementia: A nationwide cohort study, Denmark, 1977-2017.Alzheimer's & dementia (New York, N. Y.) · 2019Article
- The association between cardiovascular disease gene mutations and recurrent pregnancy loss in the Lebanese population.Molecular biology reports · 2018Article
- Maternal apolipoprotein E genotype as a potential risk factor for poor birth outcomes: The Bogalusa Heart Study.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Adverse reproductive outcomes and future risk of incident dementia: The modifying effect of genetic susceptibility.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, a relationship between recurrent pregnancy loss (RPL) and Apolipoprotein E (Apo E) gene polymorphisms has been proposed. In order to investigate the real association between Apo E polymorphisms and RPL, our meta-analysis was carried out.
methodsWe estimated the association with RPL risk under dominant and recessive models, in combination with the OR and RR with a 95% confidence interval (CI), which was used to assess the association between RPL and Apo E polymorphisms.
resultsAccording to our criterion, there were 6 studies included. The dominant model used the E4/E3 group and the OR was 1.919 (95 %CI: 1.016-3.625, I(2) = 53.8%), the RR was 1.308 (95%Cl: 1.071-1.598) suggesting that carriers of the E4 allele would have a higher risk of causing spontaneous miscarriages. In addition, the OR was 0.727 (95%CI: 0.566-0.932, I(2) = 0.0%) and RR was 0.923 (95%CI: 0.867-0.982) in a fixed model for E3/E3 homozygotes versus other genotypes, suggesting that the Apo E3 polymorphism could be a protective factor. The OR was 1.365 (95% CI: 1.029-1.811, I(2) = 0 .0%) in a fixed model comparing the E2 allele with the E3 allele, suggesting that Apo E2 polymorphisms may contribute to RPL as a risk factor. Furthermore, after conducting sensitivity analysis in the E4/E3 group, the results showed this to be consistent and the OR was 2.249 (95%CI: 1.474-3.431).
conclusionsThere is a close association between RPL and Apo E gene polymorphisms. For RPL, the Apo E4 polymorphism could be a risk factor, the Apo E3 polymorphism may be a protective factor and the Apo E2 polymorphism may be another potential risk factor.
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