ArticleEuropean journal of pediatrics2014
Characteristics of invasive pneumococcal disease in hospitalized children in Austria.
Article in European journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis.BMC medicine · 2026Pooled it
- Global Case Fatality of Bacterial Meningitis During an 80-Year Period: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Article
- Reanalysis of the Clinical and Economic Burden of Pneumococcal Disease Due to Serotypes Contained in Current and Investigational Pneumococcal Conjugate Vaccines in Children < 5 Age: A Societal Perspective.Infectious diseases and therapy · 2023Article
- Serotype distribution, antimicrobial susceptibility and molecular epidemiology of invasiveFrontiers in microbiology · 2023Article
- Clinical characteristics and serotype distribution of invasive pneumococcal disease in pediatric patients from Beijing, China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Invasive Pneumococcal Disease in Latvia in PCV10 Vaccination Era, 2012-2018.Frontiers in pediatrics · 2021Article
- Article
- Pneumococcal serotype evolution in Western Europe.BMC infectious diseases · 2015Review
- Clinical features and outcomes of invasive pneumococcal disease in a pediatric intensive care unit.BMC pediatrics · 2015Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledIn a prospective surveillance study covering all pediatric wards in Austria, 308 cases of invasive pneumococcal disease (IPD) were reported in hospitalized children <5 years of age between 2002 and 2012. Incidence was 7.1 per 100,000 per year for IPD with a case fatality rate of 3 %, and 1.9 per 100,000 per year for pneumococcal meningitis with a case fatality rate of 9 %. At hospital discharge, 17 % of the children were not fully recovered and suffered from problems such as hearing or motor deficits. Persistent sequelae 6 months after hospital discharge were present in 13 % of the children, a finding that emphasizes the seriousness of IPD. From 2007 onwards, we observed a shift of pneumococcal serotypes from those covered by the heptavalent vaccine to serotypes consequently added to 10- and 13-valent vaccines, particularly regarding serotype 19A. Among antimicrobial resistances detected, macrolide resistance was predominant; however, between 2002 and 2012, we saw an overall decrease of resistance rates.
conclusionConsidering this change of serotypes and the high rate of permanent sequelae after IPD, our data show the importance of pediatric pneumococcal vaccination and the relevance of continuous monitoring of circulating serotypes. By the end of 2012, which was the first year of universal mass vaccination against pneumococcal disease in Austria, no change in the incidence of invasive pneumococcal disease was observed yet.
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