ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2014
Personal history of diabetes, genetic susceptibility to diabetes, and risk of brain glioma: a pooled analysis of observational studies.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Diabetes mellitus and the risk of glioma: a meta-analysis.Oncotarget · 2016Pooled it
- Asthma-mediated control of optic glioma growth via T cell-microglia interactions: A mathematical model.NPJ systems biology and applications · 2026Article
- The Influence of Ethnicity on Survival from Malignant Primary Brain Tumours in England: A Population-Based Cohort Study.Cancers · 2023Article
- The risk of childhood brain tumors associated with delivery interventions: A Danish matched case-control study.Cancer epidemiology · 2022Article
- Local and Systemic Immune Dysregulation Alters Glioma Growth in Hyperglycemic Mice.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma.Cancer medicine · 2020Article
- Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Genome-Wide Association Studies in Glioma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Review
- Influence of obesity-related risk factors in the aetiology of glioma.British journal of cancer · 2018Article
- Use of MendelianFrontiers in genetics · 2018Review
- Prognostication of Survival Outcomes in Patients Diagnosed with Glioblastoma.World neurosurgery · 2018Article
- Associations between prediagnostic blood glucose levels, diabetes, and glioma.Scientific reports · 2017Article
- Maternal diabetes and incidence of childhood cancer - a nationwide cohort study and exploratory genetic analysis.Clinical epidemiology · 2017Article
- For glioma, a sweet side to diabetes.Neuro-oncology · 2016Article
- Diabetes, use of antidiabetic drugs, and the risk of glioma.Neuro-oncology · 2016Article
- Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation.Neuro-oncology · 2016Article
- Article
- Adult brain cancer in the U.S. black population: a Surveillance, Epidemiology, and End Results (SEER) analysis of incidence, survival, and trends.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Immune-related conditions and subsequent risk of brain cancer in a cohort of 4.5 million male US veterans.British journal of cancer · 2014Article
- Significant Systemic Insulin Resistance is Associated With Unique Glioblastoma Multiforme Phenotype.Clinical pathology (Thousand Oaks, Ventura County, Calif.)Article
Corrections and comments
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Authors and funding
27 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundBrain glioma is a relatively rare and fatal malignancy in adulthood with few known risk factors. Some observational studies have reported inverse associations between diabetes and subsequent glioma risk, but possible mechanisms are unclear.
methodsWe conducted a pooled analysis of original data from five nested case-control studies and two case-control studies from the United States and China that included 962 glioma cases and 2,195 controls. We examined self-reported diabetes history in relation to glioma risk, as well as effect modification by seven glioma risk-associated single-nucleotide polymorphisms (SNP). We also examined the associations between 13 diabetes risk-associated SNPs, identified from genome-wide association studies, and glioma risk. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable-adjusted logistic regression models.
resultsWe observed a 42% reduced risk of glioma for individuals with a history of diabetes (OR = 0.58; 95% CI, 0.40-0.84). The association did not differ by sex, study design, or after restricting to glioblastoma, the most common histological subtype. We did not observe any significant per-allele trends among the 13 diabetes-related SNPs examined in relation to glioma risk.
conclusionThese results support an inverse association between diabetes history and glioma risk. The role of genetic susceptibility to diabetes cannot be excluded, and should be pursued in future studies together with other factors that might be responsible for the diabetes-glioma association. IMPACT: These data suggest the need for studies that can evaluate, separately, the association between type 1 and type 2 diabetes and subsequent risk of adult glioma.
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