ArticleJournal of biomedical optics2013
Simultaneous determination of the second-harmonic generation emission directionality and reduced scattering coefficient from three-dimensional imaging of thick tissues.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Generalized 3D quasi-phase-matching model of image contrast in second harmonic generation microscopy of fibrillar collagen architectures.JPhys photonics · 2026Article
- Characterization of pathological stomach tissue using polarization-sensitive second harmonic generation microscopy.Biomedical optics express · 2023Article
- Measurement of rat and human tissue optical properties for improving the optical detection and visualization of peripheral nerves.Biomedical optics express · 2023Article
- Assessing collagen alterations in enzymatic degradation models of osteoarthritis via second harmonic generation microscopy.Osteoarthritis and cartilage · 2021Article
- Recent Advancements in Optical Harmonic Generation Microscopy: Applications and Perspectives.BME frontiers · 2021Review
- Probing ECM remodeling in idiopathic pulmonary fibrosis via second harmonic generation microscopy analysis of macro/supramolecular collagen structure.Journal of biomedical optics · 2019Article
- Second-harmonic generation microscopy analysis reveals proteoglycan decorin is necessary for proper collagen organization in prostate.Journal of biomedical optics · 2019Article
- Assessing local stromal alterations in human ovarian cancer subtypes via second harmonic generation microscopy and analysis.Journal of biomedical optics · 2017Article
- Stromal alterations in ovarian cancers via wavelength dependent Second Harmonic Generation microscopy and optical scattering.BMC cancer · 2017Article
- Endogenous Optical Signals Reveal Changes of Elastin and Collagen Organization During Differentiation of Mouse Embryonic Stem Cells.Tissue engineering. Part C, Methods · 2015Article
- Articular cartilage zonal differentiation via 3D Second-Harmonic Generation imaging microscopy.Connective tissue research · 2015Article
- Applications of second-harmonic generation imaging microscopy in ovarian and breast cancer.Perspectives in medicinal chemistry · 2015Article
- Experimental and simulation study of the wavelength dependent second harmonic generation of collagen in scattering tissues.Optics letters · 2014Article
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3 authors.
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Abstract
Second-harmonic generation (SHG) microscopy has intrinsic contrast for imaging fibrillar collagen and has shown great promise for disease characterization and diagnostics. In addition to morphology, additional information is achievable as the initially emitted SHG radiation directionality is related to subresolution fibril size and distribution. We show that by two parameter fittings, both the emission pattern (FSHG/BSHG)creation and the reduced scattering coefficient μs', can be obtained from the best fits between three-dimensional experimental data and Monte Carlo simulations. The improved simulation framework accounts for collection apertures for the detected forward and backward components. We apply the new simulation framework to mouse tail tendon for validation and show that the spectral slope of μs' obtained is similar to that from bulk optical measurements and that the (FSHG/BSHG)creation values are also similar to previous results. Additionally, we find that the SHG emission becomes increasingly forward directed at longer wavelengths, which is consistent with decreased dispersion in refractive index between the laser and SHG wavelengths. As both the spectral slope of μs' and (FSHG/BSHG)creation have been linked to the underlying tissue structure, simultaneously obtaining these parameters on a microscope platform from the same tissue provides a powerful method for tissue characterization.
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