Evidence map›Paper›PMID 24220500›Full record

ReviewChemistry and physics of lipids2014

The yeast sphingolipid signaling landscape.

David J Montefusco, Nabil Matmati, Yusuf A Hannun

Abstract readReview
In one paragraph

Review in Chemistry and physics of lipids, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Article
  2. Article
  3. Pilocarpine inhibitsMicrobiology spectrum · 2025
    Article
  4. Article
  5. Article
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  7. Article
  8. Article
  9. Review
  10. Article
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  12. Review
  13. Article
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  15. Article
  16. Article
  17. Article
  18. Modeling Calcium Signaling inFrontiers in molecular biosciences · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David J MontefuscoDept. Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, United States. Electronic address: montefus@musc.edu.
Nabil MatmatiStony Brook Cancer Center, Stony Brook University, Stony Brook, NY, United States.
Yusuf A HannunStony Brook Cancer Center, Stony Brook University, Stony Brook, NY, United States. Electronic address: Yusuf.Hannun@stonybrookmedicine.edu.

Funding

Modeling and Analysis of Yeast Sphingolipid MetabolismR01GM063265 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI HANNUN, YUSUF AWNI · 2001 to 2013
$3.4M
NIGMS NIH HHS R01 GM063265NIGMS NIH HHS R01GM063265
6 · The paper itself

Abstract

Sphingolipids are recognized as signaling mediators in a growing number of pathways, and represent potential targets to address many diseases. The study of sphingolipid signaling in yeast has created a number of breakthroughs in the field, and has the potential to lead future advances. The aim of this article is to provide an inclusive view of two major frontiers in yeast sphingolipid signaling. In the first section, several key studies in the field of sphingolipidomics are consolidated to create a yeast sphingolipidome that ranks nearly all known sphingolipid species by their level in a resting yeast cell. The second section presents an overview of most known phenotypes identified for sphingolipid gene mutants, presented with the intention of illuminating not yet discovered connections outside and inside of the field.

Indexed as

Signal TransductionHumansPhenotypeSaccharomyces cerevisiaeSphingolipidsSphingolipidsLipidomicsSignalingSphingolipidYeast

Identifiers

PMID24220500
PMCPMC4211598

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.