ArticleAutonomic neuroscience : basic & clinical2014
Dynamic remodeling of the guinea pig intrinsic cardiac plexus induced by chronic myocardial infarction.
Article in Autonomic neuroscience : basic & clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Brain‑heart axis: Neurostimulation techniques in ischemic heart disease (Review).International journal of molecular medicine · 2025Review
- Towards spatially selective efferent neuromodulation: anatomical and functional organization of cardiac fibres in the porcine cervical vagus nerve.The Journal of physiology · 2025Article
- Comparative specialization of intrinsic cardiac neurons in humans, mice and pigs.The Journal of physiology · 2025Article
- Cardiotoxicity Associated With a Low Doses of 5-FU Promotes Morphoquantitative Changes in the Intrinsic Cardiac Nervous System.Cardiovascular toxicology · 2025Article
- The Intrinsic Cardiac Nervous System: From Pathophysiology to Therapeutic Implications.Biology · 2024Review
- Heart Rate Variability Reveals Altered Autonomic Regulation in Response to Myocardial Infarction in Experimental Animals.Frontiers in cardiovascular medicine · 2022Article
- Vagally-mediated heart block after myocardial infarction associated with plasticity of epicardial neurons controlling the atrioventricular node.Frontiers in synaptic neuroscience · 2022Article
- 3D single cell scale anatomical map of sex-dependent variability of the rat intrinsic cardiac nervous system.iScience · 2021Article
- A Comprehensive Integrated Anatomical and Molecular Atlas of Rat Intrinsic Cardiac Nervous System.iScience · 2020Article
- Spinal cord neural network interactions: implications for sympathetic control of the porcine heart.American journal of physiology. Heart and circulatory physiology · 2020Article
- The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies.Nature reviews. Cardiology · 2019Review
- Cardiac innervation in acute myocardial ischaemia/reperfusion injury and cardioprotection.Cardiovascular research · 2019Review
- [Effect of spinal cord stimulation on myocardial ischemia/infarction].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2018Article
- Synaptic Plasticity in Cardiac Innervation and Its Potential Role in Atrial Fibrillation.Frontiers in physiology · 2018Review
- Bioelectronic neuromodulation of the paravertebral cardiac efferent sympathetic outflow and its effect on ventricular electrical indices.Heart rhythm · 2017Article
- Intrinsic cardiac ganglia and acetylcholine are important in the mechanism of ischaemic preconditioning.Basic research in cardiology · 2017Article
- Vagal stimulation targets select populations of intrinsic cardiac neurons to control neurally induced atrial fibrillation.American journal of physiology. Heart and circulatory physiology · 2016Article
- Translational neurocardiology: preclinical models and cardioneural integrative aspects.The Journal of physiology · 2016Review
- Co-dependence of the neural and humoral pathways in the mechanism of remote ischemic conditioning.Basic research in cardiology · 2016Article
- Vagus nerve stimulation mitigates intrinsic cardiac neuronal remodeling and cardiac hypertrophy induced by chronic pressure overload in guinea pig.American journal of physiology. Heart and circulatory physiology · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Myocardial infarction (MI) is associated with remodeling of the heart and neurohumoral control systems. The objective of this study was to define time-dependent changes in intrinsic cardiac (IC) neuronal excitability, synaptic efficacy, and neurochemical modulation following MI. MI was produced in guinea pigs by ligation of the coronary artery and associated vein on the dorsal surface of the heart. Animals were recovered for 4, 7, 14, or 50 days. Intracellular voltage recordings were obtained in whole mounts of the cardiac neuronal plexus to determine passive and active neuronal properties of IC neurons. Immunohistochemical analysis demonstrated an immediate and persistent increase in the percentage of IC neurons immunoreactive for neuronal nitric oxide synthase. Examination of individual neuronal properties demonstrated that after hyperpolarizing potentials were significantly decreased in both amplitude and time course of recovery at 7 days post-MI. These parameters returned to control values by 50 days post-MI. Synaptic efficacy, as determined by the stimulation of axonal inputs, was enhanced at 7 days post-MI only. Neuronal excitability in absence of agonist challenge was unchanged following MI. Norepinephrine increased IC excitability to intracellular current injections, a response that was augmented post-MI. Angiotensin II potentiation of norepinephrine and bethanechol-induced excitability, evident in controls, was abolished post-MI. This study demonstrates that MI induces both persistent and transient changes in IC neuronal functions immediately following injury. Alterations in the IC neuronal network, which persist for weeks after the initial insult, may lead to alterations in autonomic signaling and cardiac control.
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