ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2014
Sterile inflammation after permanent distal MCA occlusion in hypertensive rats.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Temporal Transcriptomic Differences in Stroke Between Diabetic and Non-Diabetic Mice.Journal of molecular neuroscience : MN · 2025Article
- The joint effects of inflammation and renal function status on in-hospital outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis.BMC neurology · 2024Article
- Immune compartments at the brain's borders in health and neurovascular diseases.Seminars in immunopathology · 2023Review
- Review
- Effects of Cannabidiol and Beta-Caryophyllene Alone or in Combination in a Mouse Model of Permanent Ischemia.International journal of molecular sciences · 2021Article
- Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF-κB (Nuclear Factor-κB)-Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Early neutrophil count relates to infarct size and fatal outcome after large hemispheric infarction.CNS neuroscience & therapeutics · 2020Observational
- Dl-3-n-Butylphthalide Promotes Remyelination and Suppresses Inflammation by Regulating AMPK/SIRT1 and STAT3/NF-κB Signaling in Chronic Cerebral Hypoperfusion.Frontiers in aging neuroscience · 2020Article
- Inflammation within the neurovascular unit: Focus on microglia for stroke injury and recovery.Pharmacological research · 2019Review
- Immunomodulation with Human Umbilical Cord Blood Stem Cells Ameliorates Ischemic Brain Injury - A Brain Transcriptome Profiling Analysis.Cell transplantation · 2019Article
- Correlations of C-Reactive Protein (CRP), Interleukin-6 (IL-6), and Insulin Resistance with Cerebral Infarction in Hypertensive Patients.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Dental Pulp Stem Cells: An Attractive Alternative for Cell Therapy in Ischemic Stroke.Frontiers in neurology · 2019Review
- Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview.Neural plasticity · 2019Review
- Noise-induced hearing loss: Neuropathic pain via Ntrk1 signaling.Molecular and cellular neurosciences · 2016Article
- Recurrent mild cerebral ischemia: enhanced brain injury following acute compared to subacute recurrence in the rat.BMC neuroscience · 2016Article
- Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain.Journal of visualized experiments : JoVE · 2016Article
- The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia.Current pharmaceutical design · 2016Review
- Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease.American journal of neurodegenerative disease · 2016Review
- Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease in focal cerebral ischemic rats.American journal of neurodegenerative disease · 2016Review
- Experimental animal models and inflammatory cellular changes in cerebral ischemic and hemorrhagic stroke.Neuroscience bulletin · 2015Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathophysiology of stroke is governed by immune reactions within and remote from the injured brain. Hypertension, a major cause and comorbidity of stroke, entails systemic vascular inflammation and may influence poststroke immune responses. This aspect is, however, underestimated in previous studies. Here we aimed to delineate the sequence of cellular inflammation after stroke in spontaneously hypertensive (SH) rats. Spontaneously hypertensive rats were subjected to permanent middle cerebral artery occlusion and killed after 1 or 4 days. Immune cells of the peripheral blood and those which have infiltrated the injured brain were identified and quantified by flow cytometry. The spatial distribution of myeloid cells and T lymphocytes, and the infarct volume were assessed by histology. We observed a concerted infiltration of immune cells into the ischemic brain of SH rats. At day 1, primarily neutrophils, monocytes, macrophages, and myeloid dendritic cells entered the brain, whereas the situation at day 4 was dominated by microglia, macrophages, lymphatic dendritic cells, and T cells. Postischemic inflammation did not cause secondary tissue damage during the subacute stage of experimental stroke in SH rats. Considering the intrinsic vascular pathology of SH rats, our study validates this strain for further translational research in poststroke inflammation.
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