ArticleVirology journal2013
Histopathological changes in the liver of tree shrew (Tupaia belangeri chinensis) persistently infected with hepatitis B virus.
Article in Virology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Natural Hepacivirus Infection in Tree Shrews: A Call for Routine Screening in Hepatitis Virus Research.Viruses · 2025Article
- Tree Shrew as an Emerging Small Animal Model for Human Viral Infection: A Recent Overview.Viruses · 2021Review
- A systematic study of Tupaia as a model for human acute hepatitis B infection.The Journal of veterinary medical science · 2021Article
- Animal Models of Hepatitis B Virus Infection-Success, Challenges, and Future Directions.Viruses · 2021Review
- Animal Models for the Study of Hepatitis B Virus Pathobiology and Immunity: Past, Present, and Future.Frontiers in microbiology · 2021Review
- Isolation and identification of two new strains of mammalian orthoreovirus from Chinese tree shrews.Archives of virology · 2020Article
- Pathogenesis and Immune Response Caused by Vector-Borne and Other Viral Infections in aMicroorganisms · 2019Review
- In Vivo Model Systems for Hepatitis B Virus Research.ACS infectious diseases · 2019Review
- Evolutionary biology of human hepatitis viruses.Journal of hepatology · 2019Review
- Upregulation of chemokine CXCL10 enhances chronic pulmonary inflammation in tree shrew collagen-induced arthritis.Scientific reports · 2018Article
- The tree shrew as a model for infectious diseases research.Journal of thoracic disease · 2018Review
- Tree shrew neural stem cell transplantation promotes functional recovery of tree shrews with a hemi‑sectioned spinal cord injury by upregulating nerve growth factor expression.International journal of molecular medicine · 2018Article
- Tree shrew (Zoological research · 2017Review
- Detection and analysis of tupaia hepatocytes via mAbs against tupaia serum albumin.Experimental animals · 2016Article
- Nerve growth factor promotes in vitro proliferation of neural stem cells from tree shrews.Neural regeneration research · 2016Article
- Characterization of hepatitis E virus infection in tree shrew (Tupaia belangeri chinensis).BMC infectious diseases · 2016Article
- Chronic hepatitis B virus infection and occurrence of hepatocellular carcinoma in tree shrews (Tupaia belangeri chinensis).Virology journal · 2015Article
- Therapeutic Antiviral Effect of the Nucleic Acid Polymer REP 2055 against Persistent Duck Hepatitis B Virus Infection.PloS one · 2015Article
- Tupaia belangeri as an experimental animal model for viral infection.Experimental animals · 2014Review
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn animal model for HBV that more closely approximates the disease in humans is needed. The tree shrew (Tupaia belangeri) is closely related to primates and susceptible to HBV. We previously established that neonatal tree shrews can be persistently infected with HBV in vivo, and here present a six year follow-up histopathological study of these animals.
methodsGroup A consists of six tree shrews with persistent HBV infection, group B consists of three tree shrews with suspected persistent HBV infection, while group C consists of four tree shrews free of HBV infection. Serum and liver tissues samples were collected periodically from all animals. HBV antigen and HBV antibodies were detected by ELISA and/or TRFIA. HBV DNA in serum and in liver biopsies was measured by FQ-PCR. Liver biopsies were applied for general histopathologic observation and scoring, immunohistochemical detections of HBsAg and HBcAg, and ultrastructural observation with electron microscope technique.
resultsHydropic, fatty and eosinophilic degeneration of hepatocytes, lymphocytic infiltration and hyperplasia of small bile ducts in the portal area were observed in group A. One animal infected with HBV for over six years showed multiple necrotic areas which had fused to form bridging necrosis and fibrosis, and megalocytosis. The hepatic histopathological scores of group A were higher than those of group B and C. The histopathological score correlated positively with the duration of infection.
conclusionsHepatic histopathological changes observed in chronically HBV-infected tree shrews are similar to those observed in HBV-infected humans. The tree shrew may represent a novel animal model for HBV infection.
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