ArticleMechanisms of development2014
The ETS transcription factor Etv1 mediates FGF signaling to initiate proneural gene expression during Xenopus laevis retinal development.
Article in Mechanisms of development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
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- The Role of Pea3 Transcription Factor Subfamily in the Nervous System.Molecular neurobiology · 2025Review
- Synergistic activation by Glass and Pointed promotes neuronal identity in the Drosophila eye disc.Nature communications · 2024Article
- Cell fate decisions, transcription factors and signaling during early retinal development.Progress in retinal and eye research · 2022Review
- New developments in the biology of fibroblast growth factors.WIREs mechanisms of disease · 2022Review
- Er81 Transcription Factor Fine-Tunes Striatal Cholinergic Interneuron Activity and Drives Habit Formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Differential expression profile of microRNA in yak skeletal muscle and adipose tissue during development.Genes & genomics · 2020Article
- Erinacine C Activates Transcription from a Consensus ETS DNA Binding Site in Astrocytic Cells in Addition to NGF Induction.Biomolecules · 2020Article
- Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Role of FGF9 in the Production of Neural Retina and RPE in a Pluripotent Stem Cell Model of Early Human Retinal Development.American journal of ophthalmology · 2019Article
- ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes.Scientific reports · 2018Article
- Identification and characterization of variants and a novel 4 bp deletion in the regulatory region ofMolecular genetics & genomic medicine · 2017Article
- An in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system.Developmental biology · 2015Article
- Cell cycle control, DNA damage repair, and apoptosis-related pathways control pre-ameloblasts differentiation during tooth development.BMC genomics · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Fibroblast growth factor signaling plays a significant role in the developing eye, regulating both patterning and neurogenesis. Members of the Pea3/Etv4-subfamily of ETS-domain transcription factors (Etv1, Etv4, and Etv5) are transcriptional activators that are downstream targets of FGF/MAPK signaling, but whether they are required for eye development is unknown. We show that in the developing Xenopus laevis retina, etv1 is transiently expressed at the onset of retinal neurogenesis. We found that etv1 is not required for eye specification, but is required for the expression of atonal-related proneural bHLH transcription factors, and is also required for retinal neuron differentiation. Using transgenic reporters we show that the distal atoh7 enhancer, which is required for the initiation of atoh7 expression in the Xenopus retina, is responsive to both FGF signaling and etv1 expression. Thus, we conclude that Etv1 acts downstream of FGF signaling to regulate the initiation of neurogenesis in the Xenopus retina.
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