ArticleEuropean journal of clinical nutrition2014
Investigating the causal effect of vitamin D on serum adiponectin using a Mendelian randomization approach.
Article in European journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Association of selected adipokines with vitamin D deficiency in children with inflammatory bowel disease.BMC pediatrics · 2024Article
- Could Vitamin D Be Effective in Prevention of Preeclampsia?Nutrients · 2021Review
- The causal role of circulating vitamin D concentrations in human complex traits and diseases: a large-scale Mendelian randomization study.Scientific reports · 2021Article
- Associations of Serum 25-Hydroxyvitamin D with Adiposity and At-Risk Lipid Profile Differ for Indigenous (Orang Asli) Male and Female Adults of Peninsular Malaysia.International journal of environmental research and public health · 2020Article
- Phenome-wide Mendelian-randomization study of genetically determined vitamin D on multiple health outcomes using the UK Biobank study.International journal of epidemiology · 2019Article
- Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.Endocrine reviews · 2019Review
- Relationship of serum Vitamin D concentrations with Adipokines and Cardiometabolic risk among non-Hispanic black type 2 diabetic and non-diabetic subjects: a cross-sectional study.BMC nutrition · 2018Article
- Vitamin-D concentrations, cardiovascular risk and events - a review of epidemiological evidence.Reviews in endocrine & metabolic disorders · 2017Review
- Vitamin D and cardiovascular disease prevention.Nature reviews. Cardiology · 2016Review
- Circulating Endothelial Microparticles and Correlation of Serum 1,25-Dihydroxyvitamin D with Adiponectin, Nonesterified Fatty Acids, and Glycerol from Middle-Aged Men in China.BioMed research international · 2016Article
- Can skin exposure to sunlight prevent liver inflammation?Nutrients · 2015Review
- Article
- Results of the META-Health Study Suggest Pathways by Which Vitamin D Affect Obesity and Cardiovascular Risk through Adiponectin Levels may Require Further Characterization in Subgroups.Frontiers in public health · 2014Article
- No association between loss-of-function mutations in filaggrin and diabetes, cardiovascular disease, and all-cause mortality.PloS one · 2013Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThe aim was to examine the causal effect of vitamin D on serum adiponectin using a multiple instrument Mendelian randomization approach. SUBJECTS/
methodsSerum 25-hydroxy vitamin D (25(OH)D) and serum total or high molecular weight (HMW) adiponectin were measured in two Danish population-based studies: the Inter99 study (6405 adults, 30-60 years) conducted in 1999-2001, and the MONICA10 study (2656 adults, 41-71 years) conducted in 1993-1994.
resultsIn the Inter99 study, serum 25(OH)D was positively associated with total adiponectin (the effect estimate in % per doubling of 25(OH)D was 4.78, 95% CI: 1.96, 7.68, P<0.001). Using variations in the vitamin D-binding protein gene and the filaggrin gene as instrumental variables, the causal effect in % was estimated to 61.46, 95% CI: 17.51, 120.28, P=0.003 higher adiponectin per doubling of 25(OH)D. In the MONICA10 cohort, no significant association was observed between the serum concentrations of 25(OH)D and HMW adiponectin (the effect estimate in % per doubling of 25(OH)D was -1.51, 95% CI: -5.80, 2.98, P=0.50), although the instrumental variables analysis to some extent supported a positive causal association (the effect estimate in % per doubling of 25(OH)D was 37.13, 95% CI: -3.67, 95.20, P=0.080).
conclusionsThe results indicate a possible causal association between serum 25(OH)D and total adiponectin. However, the association was not replicated for HMW adiponectin. Thus, further studies are needed to confirm a causal relationship.
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