ArticleArchives of environmental & occupational health2015
Pesticides, gene polymorphisms, and bladder cancer among Egyptian agricultural workers.
Article in Archives of environmental & occupational health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Association betweenDisease markers · 2018Pooled it
- Pesticide exposure and risk of bladder cancer: A meta-analysis.Oncotarget · 2016Pooled it
- The association between NQO1 Pro187Ser polymorphism and bladder cancer susceptibility: a meta-analysis of 15 studies.PloS one · 2015Pooled it
- Reliable LC-MS/MS method integrated with a linear retention index approach for multiresidue pesticide analysis in hemp seed oil.Analytical and bioanalytical chemistry · 2026Article
- Sex differences in bladder cancer: understanding biological and clinical implications.Biology of sex differences · 2025Review
- Assessment of organochlorine pesticide residues in agricultural soils of southern Nigeria and analysis of potential health risks.Toxicology reports · 2024Article
- Risk Factors Associated with Urothelial Bladder Cancer.International journal of environmental research and public health · 2024Review
- Uncovering the epidemiology of bladder cancer in the Arab world: A review of risk factors, molecular mechanisms, and clinical features.Asian journal of urology · 2024Review
- Rapid and specific detection of thiabendazole: enzymatic digestion-enabled fluorescent aptasensor.Analytical and bioanalytical chemistry · 2024Article
- Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures.Heliyon · 2024Review
- Pesticide biosensors: trends and progresses.Analytical and bioanalytical chemistry · 2023Review
- Exposure to Airborne Pesticides and Its Residue in Blood Serum of Paddy Farmers in Malaysia.International journal of environmental research and public health · 2022Article
- An Institution-Based Demographic Study of Urinary Bladder Cancer from North India.Indian journal of surgical oncology · 2022Article
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- Relationship between cumulative exposure to pesticides and sleep disorders among greenhouse vegetable farmers.BMC public health · 2019Article
- Environmental Health Research in Africa: Important Progress and Promising Opportunities.Frontiers in genetics · 2019Review
- Modulatory role of GSTT1 and GSTM1 in Punjabi agricultural workers exposed to pesticides.Environmental science and pollution research international · 2018Article
- Egypt: The flatworm's revenge.Nature · 2017Article
- Nonoccupational exposure to agricultural work and risk of urinary bladder cancer among Egyptian women.Archives of environmental & occupational health · 2017Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
This study examined the associations between pesticide exposure, genetic polymorphisms for NAD(P)H: quinone oxidoreductase I (NQO1) and superoxide dismutase 2 (SOD2), and urinary bladder cancer risk among male agricultural workers in Egypt. Logistic regression was used to analyze data from a multicenter case-control study and estimate adjusted odds ratio (OR) and 95% confidence interval (CI). Exposure to pesticides was associated with increased bladder cancer risk (odds ratio (95% confidence interval): 1.68 (1.23-2.29)) in a dose-dependent manner. The association was slightly stronger for urothelial (1.79 (1.25-2.56)) than for squamous cell (1.55 (1.03-2.31)), and among participants with combined genotypes for low NQO1 and high SOD2 (2.14 (1.19-3.85)) activities as compared with those with high NQO1 and low SOD2 genotypes (1.53 (0.73-3.25)). In conclusion, among male agricultural workers in Egypt, pesticide exposure is associated with bladder cancer risk and possibly modulated by genetic polymorphism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.