Trial reportBMC musculoskeletal disorders2013
The PICO project: aquatic exercise for knee osteoarthritis in overweight and obese individuals.
Trial report in BMC musculoskeletal disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01832545 (The PICO Project), which is not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The PICO Project: Aquatic Exercise for Knee Osteoarthritis in Overweight and Obese Individuals
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis.Frontiers in physiology · 2021Pooled it
- The role of mineral elements and other chemical compounds used in balneology: data from double-blind randomized clinical trials.International journal of biometeorology · 2017Pooled it
- Effectiveness of aquatic exercise for treatment of knee osteoarthritis: Systematic review and meta-analysis.Zeitschrift fur Rheumatologie · 2015Pooled it
- The PLE(2)NO self-management and exercise program for knee osteoarthritis: Study Protocol for a Randomized Controlled Trial.BMC musculoskeletal disorders · 2016Trial
- Hydrotherapy for Overweight and Obesity: A Systematic Review of Anthropometric and Lipid Outcomes.Cureus · 2026Review
- How Swimming Modulates Inflammatory Pathways in Pain, Neurodegenerative, and Metabolic Disorders.Brain sciences · 2025Review
- Aquatic versus land-based exercise for knee osteoarthritis: a randomized controlled trial.Korean journal of family medicine · 2025Article
- Global research trends in aquatic exercise therapy for musculoskeletal disorders: a bibliometric analysis.Journal of rehabilitation medicine · 2025Article
- Optimal exercise modalities and doses for therapeutic management of osteoarthritis of the knee.Frontiers in aging · 2025Review
- The effect of aquatherapy on pain intensity and performance in patients with osteoarthritis.Journal of family medicine and primary care · 2024Article
- Dose-response relationship between 15 weeks of running and aerobic fitness: a retrospective analysis based on the fun running program.BMC public health · 2024Article
- Program with last minute abstracts of the Padua Days on Muscle and Mobility Medicine, 27 February - 2 March, 2024 (2024Pdm3).European journal of translational myology · 2024Article
- Assessment of an IMU-Based Experimental Set-Up for Upper Limb Motion in Obese Subjects.Sensors (Basel, Switzerland) · 2023Article
- Swimming prevents cell death of chondrocytes via PI3K/AKT pathway in an experimental model.Journal of orthopaedic surgery and research · 2023Article
- Effects of Aquatic Exercises for Patients with Osteoarthritis: Systematic Review with Meta-Analysis.Healthcare (Basel, Switzerland) · 2022Review
- Systematic review of aquatic physical exercise programs on functional fitness in older adults.European journal of translational myology · 2021Article
- Kinetic Analysis of Water Fitness Exercises: Contributions for Strength Development.International journal of environmental research and public health · 2019Article
- Exercise as a prescription for patients with various diseases.Journal of sport and health science · 2019Review
- Osteoarthritis, Exercise, and Tissue Engineering: A Stimulating Triad for Health Professionals.Journal of aging research · 2019Review
- Effect of aquatic versus land based exercise programs on physical performance in severely burned patients: a randomized controlled trial.Journal of physical therapy science · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAquatic exercise is recommended by the Osteoarthritis Research Society (OARSI), by the American College of Rheumatology (ACR) and by the European League Against Rheumatism (EULAR) as a nonpharmacological method of controlling the knee osteoarthritis (KOA) symptoms. Moreover, given that weight loss results in a reduction of the load that is exerted upon the knee during daily activities, obesity is also considered to be a modifiable risk factor for the development and or exacerbation of KOA. The implementation of an exercise based weight loss program may, however, itself be limited by the symptoms of KOA. The aquatic program against osteoarthritis (termed "PICO" in Portuguese) prioritizes the control of symptoms and the recovery of functionality, with an attendant increase in the patient's physical activity level and, consequently, metabolic rate. Our laboratory is assessing the effectiveness of 3 months of PICO on the symptoms of KOA, on physical function, on quality of life and on gait. In addition, PICO shall examine the effects of said exercise intervention on inflammatory biomarkers, psychological health, life style and body composition. METHODS/
designThe trial is a prospective, single-blinded, randomized controlled trial, and involves 50 overweight and obese adults (BMI = 28-43.5 kg/m²; age 40-65 yrs) with radiographic KOA. The participants are randomly allocated into either an educational attention (control) group or an aquatic (exercise program) group. This paper describes the experimental protocol that is used in the PICO project. DISCUSSION: The PICO program shall provide insight into the effectiveness of an aquatic exercise program in the control of KOA symptoms and in the improvement of the quality of life. As such, they are likely to prove a useful reference to health professionals who intend to implement any kind of therapeutic intervention based around aquatic exercise.
trial registrationNCT01832545.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.