Evidence map›Paper›PMID 24219610›Full record

ArticleNeuropsychology2014

Memory consolidation in aging and MCI after 1 week.

Christine M Walsh, Sarah Wilkins, Brianne Magouirk Bettcher, Christopher R Butler, Bruce L Miller, Joel H Kramer

Abstract read
In one paragraph

Article in Neuropsychology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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  4. Review
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  10. Encoding-related brain activity and accelerated forgetting in transient epileptic amnesia.Cortex; a journal devoted to the study of the nervous system and behavior · 2019
    Article
  11. The evolution of accelerated long-term forgetting: Evidence from the TIME study.Cortex; a journal devoted to the study of the nervous system and behavior · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christine M WalshMemory and Aging Center, Department of Neurology, University of California, San Francisco.
Sarah WilkinsMemory and Aging Center, Department of Neurology, University of California, San Francisco.
Brianne Magouirk BettcherMemory and Aging Center, Department of Neurology, University of California, San Francisco.
Christopher R ButlerDepartment of Clinical Neurology, University of Oxford.
Bruce L MillerMemory and Aging Center, Department of Neurology, University of California, San Francisco.
Joel H KramerMemory and Aging Center, Department of Neurology, University of California, San Francisco.

Funding

PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, YADONG · 2004 to 2018
$27.1M
Prediction of cognitive decline with structural, diffusion, and perfusion MRIR01AG010897 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI WEINER, MICHAEL W · 1992 to 2013
$9.4M
Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
Biological Predictors Of Brain Aging Trajectories Diversity Supplement: African American Outreach And The Intersection Between Social Determinants Of Health And Biomarkers Of Degenerative DiseaseRF1AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2020 to 2021
$5.3M
Cognitive and Neural Correlates of Inflammation in Healthy Older AdultsK23AG042492 · NIA · UNIVERSITY OF COLORADO DENVER · PI BETTCHER, BRIANNE MAGOUIRK · 2012 to 2016
$716k
Medical Research Council MR/K010395/1NIA NIH HHS AG010897NIA NIH HHS AG032289NIA NIH HHS K23 AG042492NIA NIH HHS P50 AG023501NIA NIH HHS P50AG023501NIA NIH HHS R01 AG010897NIA NIH HHS R01 AG032289NIA NIH HHS RF1 AG032289
6 · The paper itself

Abstract

objectiveTo assess consolidation in amnestic mild cognitive impairment (aMCI), controlling for differences in initial learning and using a protracted delay period for recall.

method15 individuals with aMCI were compared with 15 healthy older adult controls on a story learning task. Subjects were trained to criteria to equalize initial learning across subjects. Recall was tested at both the 30-min typically used delay and a 1-week delay used to target consolidation.

resultsUsing repeated measures ANOVAs adjusted for age, we found group × time point interactions across the entire task between the final trial and 30-min delay, and again between the 30-min and 1-week delay periods, with aMCI having greater declines in recall as compared with controls. Significant group main effects were also found, with aMCI recalling less than controls.

conclusionConsolidation was impaired in aMCI as compared with controls. Our findings indicate that aMCI-related performance typically measured at 30 min underestimates aMCI-associated memory deficits. This is the first study to isolate consolidation by controlling for initial learning differences and using a protracted delay period to target consolidation in an aMCI sample.

Indexed as

LearningMemoryAgedAgingAmnesiaCognitive DysfunctionFemaleHumansMaleMental Recall

Identifiers

PMID24219610
PMCPMC4211844

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.