ArticleJournal of the American Geriatrics Society2013
Changes in physical performance in older women according to presence and treatment of diabetes mellitus.
Article in Journal of the American Geriatrics Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Polypharmacy and Malnutrition Management of Elderly Perioperative Patients with Cancer: A Systematic Review.Nutrients · 2021Pooled it
- Long-term impact of Diabetes Prevention Program interventions on walking endurance.Frontiers in public health · 2024Trial
- Association of Intensive Lifestyle and Metformin Interventions With Frailty in the Diabetes Prevention Program Outcomes Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Trial
- Personalised Approach to the Management of Older People with Type 2 Diabetes Mellitus-A Comprehensive Narrative Review.Journal of personalized medicine · 2026Review
- The bidirectional relationship between diabetes and poor muscle function in older adults: data from two population-based studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Article
- What Do We Know About Prevention of Frailty in Women?American journal of lifestyle medicine · 2025Review
- Practical Considerations in the Management of Frail Older People with Diabetes.Diseases (Basel, Switzerland) · 2025Review
- Frailty incidence by diabetes treatment regimens in older adults with diabetes mellitus in the ASPirin in Reducing Events in the Elderly Study.GeroScience · 2025Observational
- Effects of Hypoglycemic Agents on The Musculoskeletal System: A Comprehensive Review.Drug design, development and therapy · 2025Review
- Association between oral health and physical performance in Brazilian older adults: SABE cohort study.BMC oral health · 2024Article
- Diabetic Sarcopenia. A proposed muscle screening protocol in people with diabetes : Expert document.Reviews in endocrine & metabolic disorders · 2024Review
- Imaging of Sarcopenia in Type 2 Diabetes Mellitus.Clinical interventions in aging · 2024Review
- Repurposing Drugs for Diabetes Mellitus as Potential Pharmacological Treatments for Sarcopenia - A Narrative Review.Drugs & aging · 2023Review
- Identification of the cuproptosis-related hub genes and therapeutic agents for sarcopenia.Frontiers in genetics · 2023Article
- Sex differences in frailty of geriatric outpatients with type 2 diabetes mellitus: a multicentre cross-sectional study.Scientific reports · 2022Article
- Hypoglycaemic therapy in frail older people with type 2 diabetes mellitus-a choice determined by metabolic phenotype.Aging clinical and experimental research · 2022Review
- Diabetes, sarcopenia and chronic kidney disease; the Screening for CKD among Older People across Europe (SCOPE) study.BMC geriatrics · 2022Article
- Review
- Risk Factors for Incident Fracture in Older Adults With Type 2 Diabetes: The Framingham Heart Study.Diabetes care · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesTo determine whether older women with diabetes mellitus have a greater longitudinal decline in physical performance than those without and whether any decline differs according to insulin sensitizer use.
designProspective cohort study.
settingBaltimore, Maryland; Minneapolis, Minnesota; Portland, Oregon; and the Monongahela, Pennsylvania.
participantsCommunity-dwelling women (mean age 78.5 ± 3.6) enrolled in the Study of Osteoporotic Fractures in 1997-98 and restudied 4.9 ± 0.6 years later (N = 2,864). MEASUREMENTS: Women were categorized as having no diabetes mellitus (n = 2,680) or having diabetes mellitus (n = 184). A prescription medication inventory was used to determine use of insulin sensitizers (metformin and thiazolidinedione). The outcomes were longitudinal changes in physical performance measures, including grip strength, usual walk speed, and rapid walk speed.
resultsEstimates from fully adjusted models showed that women with diabetes mellitus had greater declines in usual walk speed (-0.16 m/s, 95% confidence interval (CI) = -0.19 to -0.14) and rapid walk speed (-0.21 m/s, 95% CI = -0.24 to -0.17) than those without (usual walk speed -0.11 m/s, 95% CI = -0.12 to -0.11, P < .001; rapid walk speed -0.15 m/s, 95% CI = -0.16 to -0.14; P = .005). Women with diabetes mellitus taking insulin sensitizers had less decline in usual walk speed than those not taking insulin sensitizers (P < .001). Declines in grip strength did not differ significantly by diabetes mellitus status or insulin sensitizer use.
conclusionOlder women with diabetes mellitus have a greater decline in walk speed, but not grip strength, than older women without diabetes mellitus. Clinical studies in older adults to determine whether diabetes mellitus treatments such as insulin sensitizers can prevent loss in walk speed and mobility are needed.
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