ReviewVeterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
Invited review--neuroimaging response assessment criteria for brain tumors in veterinary patients.
Review in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The Definitive-Intent 10-Fraction Radiotherapy Protocol ('The Zurich Protocol') Yields Lasting Tumour Control and Survival in Dogs With Intracranial Meningiomas.Veterinary and comparative oncology · 2026Article
- Prognostic Value of Magnetic Resonance Imaging Defined Extent of Surgical Resection in Dogs With Intracranial Meningiomas.Veterinary and comparative oncology · 2026Article
- Neurologic improvement and tumor shrinkage after radiotherapy in dogs with imaging-based intracranial neoplasia.Journal of veterinary internal medicine · 2026Article
- Systemic mRNA vaccines elicit rapid immune activation in canine brain tumors.Journal for immunotherapy of cancer · 2025Article
- Oligodendroglioma pseudoprogression after radiotherapy in a dog: a case report.Frontiers in veterinary science · 2025Article
- Evaluation ofFrontiers in veterinary science · 2023Article
- Intracranial Virotherapy for a Canine Hemangioma.International journal of molecular sciences · 2022Article
- Comparison of linear and volumetric criteria for the determination of therapeutic response in dogs with intracranial gliomas.Journal of veterinary internal medicine · 2022Article
- Phase I trial of convection-enhanced delivery of IL13RA2 and EPHA2 receptor targeted cytotoxins in dogs with spontaneous intracranial gliomas.Neuro-oncology · 2021Article
- Definitive-intent uniform megavoltage fractioned radiotherapy protocol for presumed canine intracranial gliomas: retrospective analysis of survival and prognostic factors in 38 cases (2013-2019).BMC veterinary research · 2020Article
- Companion animal models of neurological disease.Journal of neuroscience methods · 2020Review
- Canine Primary Intracranial Cancer: A Clinicopathologic and Comparative Review of Glioma, Meningioma, and Choroid Plexus Tumors.Frontiers in oncology · 2019Review
- Consensus recommendations on standardized magnetic resonance imaging protocols for multicenter canine brain tumor clinical trials.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2018Article
- Dogs are man's best friend: in sickness and in health.Neuro-oncology · 2017Review
- Computed Tomography and Magnetic Resonance Imaging Are Equivalent in Mensuration and Similarly Inaccurate in Grade and Type Predictability of Canine Intracranial Gliomas.Frontiers in veterinary science · 2017Article
- Frameless stereotactic volumetric modulated arc radiotherapy of brachial plexus tumours in dogs: 10 cases.The British journal of radiology · 2017Article
- Optic nerve astrocytoma in a dog.Clinical case reports · 2016Article
- Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients.Neuro-oncology · 2016Review
- A prospective evaluation of succinct prednisone tapering after brain tumor irradiation in dogs.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The evaluation of therapeutic response using cross-sectional imaging techniques, particularly gadolinium-enhanced MRI, is an integral part of the clinical management of brain tumors in veterinary patients. Spontaneous canine brain tumors are increasingly recognized and utilized as a translational model for the study of human brain tumors. However, no standardized neuroimaging response assessment criteria have been formulated for use in veterinary clinical trials. Previous studies have found that the pathophysiologic features inherent to brain tumors and the surrounding brain complicate the use of the response evaluation criteria in solid tumors (RECIST) assessment system. Objectives of this review are to describe strengths and limitations of published imaging-based brain tumor response criteria and propose a system for use in veterinary patients. The widely used human Macdonald and response assessment in neuro-oncology (RANO) criteria are reviewed and described as to how they can be applied to veterinary brain tumors. Discussion points will include current challenges associated with the interpretation of brain tumor therapeutic responses such as imaging pseudophenomena and treatment-induced necrosis, and how advancements in perfusion imaging, positron emission tomography, and magnetic resonance spectroscopy have shown promise in differentiating tumor progression from therapy-induced changes. Finally, although objective endpoints such as MR imaging and survival estimates will likely continue to comprise the foundations for outcome measures in veterinary brain tumor clinical trials, we propose that in order to provide a more relevant therapeutic response metric for veterinary patients, composite response systems should be formulated and validated that combine imaging and clinical assessment criteria.
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