ArticleBMC infectious diseases2013
CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Copy number variation of CCL3L1 among three major ethnic groups in Malaysia.BMC genetics · 2020Article
- Population-wide copy number variation calling using variant call format files from 6,898 individuals.Genetic epidemiology · 2020Article
- HumanWellcome open research · 2018Article
- Population genetics of immune-related multilocus copy number variation in Native Americans.Journal of the Royal Society, Interface · 2017Article
- Copy number variation of genes involved in the hepatitis C virus-human interactome.Scientific reports · 2016Article
- Defensin gene variation and HIV/AIDS: a comprehensive perspective needed.Journal of leukocyte biology · 2016Review
- SRBreak: A Read-Depth and Split-Read Framework to Identify Breakpoints of Different Events Inside Simple Copy-Number Variable Regions.Frontiers in genetics · 2016Article
- Complex and multi-allelic copy number variation in human disease.Briefings in functional genomics · 2015Review
- An evolutionary history of defensins: a role for copy number variation in maximizing host innate and adaptive immune responses.Frontiers in immunology · 2015Review
- Human gene copy number variation and infectious disease.Human genetics · 2014Review
- Inferring mechanisms of copy number change from haplotype structures at the human DEFA1A3 locus.BMC genomics · 2014Article
- Genetics of Sub-Saharan African Human Population: Implications for HIV/AIDS, Tuberculosis, and Malaria.International journal of evolutionary biology · 2014Review
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundThe role of copy number variation of the CCL3L1 gene, encoding MIP1α, in contributing to the host variation in susceptibility and response to HIV infection is controversial. Here we analyse a sub-Saharan African cohort from Tanzania and Ethiopia, two countries with a high prevalence of HIV-1 and a high co-morbidity of HIV with tuberculosis.
methodsWe use a form of quantitative PCR called the paralogue ratio test to determine CCL3L1 gene copy number in 1134 individuals and validate our copy number typing using array comparative genomic hybridisation and fiber-FISH.
resultsWe find no significant association of CCL3L1 gene copy number with HIV load in antiretroviral-naïve patients prior to initiation of combination highly active anti-retroviral therapy. However, we find a significant association of low CCL3L1 gene copy number with improved immune reconstitution following initiation of highly active anti-retroviral therapy (p = 0.012), replicating a previous study.
conclusionsOur work supports a role for CCL3L1 copy number in immune reconstitution following antiretroviral therapy in HIV, and suggests that the MIP1α -CCR5 axis might be targeted to aid immune reconstitution.
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