SynthesisBritish journal of clinical pharmacology2014
Metabolic disturbances and renal stone promotion on treatment with topiramate: a systematic review.
Synthesis in British journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03354507 (Use of Sodium Bicarbonate to Alkalinize Serum/Urine in Pediatric Patients Treated With Topiramate), which is not on this map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Sodium Bicarbonate to Alkalinize Serum/Urine in Pediatric Patients Treated With Topiramate (Pilot Study)
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- A systematic review on urolithiasis in children with neurological disorders.World journal of urology · 2024Pooled it
- Pooled it
- Practice guideline recommendations summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders.Neurology · 2019Guideline
- Efficacy and Safety of Topiramate for Essential Tremor: A Meta-Analysis of Randomized Controlled Trials.Medicine · 2015Pooled it
- Review of Physiology, Pathology, and Pharmacology of Voltage-Gated Sodium Channels in Regards to the Potential Role of NaV 1.8 Selective Inhibitor, Suzetrigine, for Chronic Pain Management.Journal of pain research · 2026Review
- Comparison of Thiazide Versus Alkali for Kidney Stone Recurrence Among Individuals With Hypocitraturia and High Urine pH.Kidney medicine · 2025Article
- Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug-drug interactions.CPT: pharmacometrics & systems pharmacology · 2025Article
- The clinical utility of urolithiasis morphology assessment for perioperative stone composition determination.Central European journal of urology · 2025Article
- A cross-language analysis of urolithiasis patient online materials: Assessment across 24 European languages.Central European journal of urology · 2025Article
- An exploratory study evaluated the 30 most commonly reported medications in the United States food and drug administration's adverse event reporting system that are associated with the occurrence of kidney stones.Frontiers in pharmacology · 2024Article
- The characteristics and optimal treatment of urolithiasis associated with tuberous sclerosis complex.International urology and nephrology · 2021Article
- Managing Essential Tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Drug-Induced Urolithiasis in Pediatric Patients.Paediatric drugs · 2019Review
- Review
- Drug-Induced Kidney Stones and Crystalline Nephropathy: Pathophysiology, Prevention and Treatment.Drugs · 2018Review
- Topiramate induced metabolic acidosis and kidney stones - a case study.Biochemia medica · 2017Article
- The frequency and severity of metabolic acidosis related to topiramate.The Journal of international medical research · 2016Article
- Factors associated with patient recall of individualized dietary recommendations for kidney stone prevention.European journal of clinical nutrition · 2016Article
- Systematic Adverse Drug Reaction Monitoring of Patients Under Newer Antiepileptic Drugs Using Routine Clinical Data of Inpatients.Drugs - real world outcomes · 2016Article
- Topiramate as a rare cause of reversible Fanconi syndrome and acute kidney injury: a case report and literature review.Journal of community hospital internal medicine perspectives · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe use of topiramate, which is prescribed for the management of epilepsy, for migraine headache prophylaxis and as a weight-loss agent, has been associated with the development of metabolic acidosis, hypokalaemia and renal stone disease. We systematically reviewed all the literature.
methodsThe systematic review of the literature was realized using the principles underlying the UK Economic and Social Research Council guidance on the conduct of narrative synthesis and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.
resultsFourty-seven reports published between 1996 and 2013 were retained for the final analysis. Five case-control studies and six longitudinal studies addressed the effect of topiramate on acid-base and potassium balance. A significant tendency towards mild-to-moderate hyperchloraemic metabolic acidosis (with bicarbonate ≤21.0 mmol l(-1) in approximately every third case) and mild hypokalaemia (with potassium ≤3.5 mmol l(-1) in 10% of the cases) was noted on treatment with topiramate, which was similar in children and adults. A single study observed that topiramate causes mild hyperuricaemia in male adults. A tendency towards hypocitraturia, a recognized promoter of renal stone formation, was noted in all patients on topiramate.
conclusionsIncreasing evidence supports the use of topiramate. Topiramate is generally well tolerated, and serious adverse events are rare. Nonetheless, the present systematic review of the literature indicates that its use is linked with the development of acidosis, hypokalaemia, hyperuricaemia and hypocitraturia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.