ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2013
The structure and evolution of cis-regulatory regions: the shavenbaby story.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed.
- The cellular basis of locomotor evolution: insights from larval insects.Current opinion in behavioral sciences · 2026Article
- Distinct mechanisms decommission redundant enhancers to facilitate phenotypic evolution.Science advances · 2026Article
- Heterochrony in orthodenticle expression is associated with ommatidial size variation between Drosophila species.BMC biology · 2025Article
- Co-option of the trichome-forming network initiated the evolution of a morphological novelty in Drosophila eugracilis.Current biology : CB · 2024Article
- The Density of Regulatory Information Is a Major Determinant of Evolutionary Constraint on Noncoding DNA in Drosophila.Molecular biology and evolution · 2024Article
- A developmental atlas of male terminalia across twelve species ofFrontiers in cell and developmental biology · 2024Article
- Divergent combinations of cis-regulatory elements control the evolution of phenotypic plasticity.PLoS biology · 2023Article
- Mutational scans reveal differential evolvability ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Theme and variation in the evolution of insect sex determination.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Review
- Characterisation of the role and regulation ofFrontiers in cell and developmental biology · 2023Article
- Lost in translation: Molecular basis of reduced flower coloration in a self-pollinated monkeyflower (Science advances · 2022Article
- Genetic basis of speciation and adaptation: from loci to causative mutations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Olfactory receptor choice: a case study for gene regulation in a multi-enhancer system.Current opinion in genetics & development · 2022Review
- From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation.Trends in genetics : TIG · 2021Review
- Article
- Pri smORF Peptides Are Wide Mediators of Ecdysone Signaling, Contributing to Shape Spatiotemporal Responses.Frontiers in genetics · 2021Article
- Evolution of wing pigmentation in Drosophila: Diversity, physiological regulation, and cis-regulatory evolution.Development, growth & differentiation · 2020Review
- Article
- Gene Regulatory and Expression Differences between Mouse and Pig Limb Buds Provide Insights into the Evolutionary Emergence of Artiodactyl Traits.Cell reports · 2020Article
- A homeotic shift late in development drives mimetic color variation in a bumble bee.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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2 authors.
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Abstract
In this paper, we provide a historical account of the contribution of a single line of research to our current understanding of the structure of cis-regulatory regions and the genetic basis for morphological evolution. We revisit the experiments that shed light on the evolution of larval cuticular patterns within the genus Drosophila and the evolution and structure of the shavenbaby gene. We describe the experiments that led to the discovery that multiple genetic changes in the cis-regulatory region of shavenbaby caused the loss of dorsal cuticular hairs (quaternary trichomes) in first instar larvae of Drosophila sechellia. We also discuss the experiments that showed that the convergent loss of quaternary trichomes in D. sechellia and Drosophila ezoana was generated by parallel genetic changes in orthologous enhancers of shavenbaby. We discuss the observation that multiple shavenbaby enhancers drive overlapping patterns of expression in the embryo and that these apparently redundant enhancers ensure robust shavenbaby expression and trichome morphogenesis under stressful conditions. All together, these data, collected over 13 years, provide a fundamental case study in the fields of gene regulation and morphological evolution, and highlight the importance of prolonged, detailed studies of single genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.