ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2013
Enhancer turnover and conserved regulatory function in vertebrate evolution.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Functional characteristics and computational model of abundant hyperactive loci in the human genome.eLife · 2024Article
- Evidence for compensatory evolution within pleiotropic regulatory elements.Genome research · 2024Article
- Functional characteristics and computational model of abundant hyperactive loci in the human genome.bioRxiv : the preprint server for biology · 2024Article
- A mammalian tripartite enhancer cluster controls hypothalamicProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Accelerated Evolution Analysis Uncovers PKNOX2 as a Key Transcription Factor in the Mammalian Cochlea.Molecular biology and evolution · 2023Article
- The GRN concept as a guide for evolutionary developmental biology.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Article
- The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements.Development, growth & differentiation · 2021Article
- Deep Convergence, Shared Ancestry, and Evolutionary Novelty in the Genetic Architecture ofGenetics · 2020Article
- Towards a map of cis-regulatory sequences in the human genome.Nucleic acids research · 2018Article
- Dynamic evolution of regulatory element ensembles in primate CD4Nature ecology & evolution · 2018Article
- Conserved non-coding elements: developmental gene regulation meets genome organization.Nucleic acids research · 2017Review
- Human evolution: the non-coding revolution.BMC biology · 2017Review
- Molecular and functional genetics of the proopiomelanocortin gene, food intake regulation and obesity.FEBS letters · 2017Review
- Comparative analyses of super-enhancers reveal conserved elements in vertebrate genomes.Genome research · 2017Article
- Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration.Current neurology and neuroscience reports · 2016Review
- Compensatory Drift and the Evolutionary Dynamics of Dosage-Sensitive Duplicate Genes.Genetics · 2016Article
- Mechanisms of Evolutionary Innovation Point to Genetic Control Logic as the Key Difference Between Prokaryotes and Eukaryotes.Journal of molecular evolution · 2015Article
- Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Unraveling the Tangled Skein: The Evolution of Transcriptional Regulatory Networks in Development.Annual review of genomics and human genetics · 2015Review
- Evidence for deep regulatory similarities in early developmental programs across highly diverged insects.Genome biology and evolution · 2014Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Mutations in regulatory regions including enhancers are an important source of variation and innovation during evolution. Enhancers can evolve by changes in the sequence, arrangement and repertoire of transcription factor binding sites, but whole enhancers can also be lost or gained in certain lineages in a process of turnover. The proopiomelanocortin gene (Pomc), which encodes a prohormone, is expressed in the pituitary and hypothalamus of all jawed vertebrates. We have previously described that hypothalamic Pomc expression in mammals is controlled by two enhancers-nPE1 and nPE2-that are derived from transposable elements and that presumably replaced the ancestral neuronal Pomc regulatory regions. Here, we show that nPE1 and nPE2, even though they are mammalian novelties with no homologous counterpart in other vertebrates, nevertheless can drive gene expression specifically to POMC neurons in the hypothalamus of larval and adult transgenic zebrafish. This indicates that when neuronal Pomc enhancers originated de novo during early mammalian evolution, the newly created cis- and trans-codes were similar to the ancestral ones. We also identify the neuronal regulatory region of zebrafish pomca and confirm that it is not homologous to the mammalian enhancers. Our work sheds light on the process of gene regulatory evolution by showing how a locus can undergo enhancer turnover and nevertheless maintain the ancestral transcriptional output.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.